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Dexmethylphenidate-associated hemorrhagic bullous IgA vasculitis
Journal article   Open access   Peer reviewed

Dexmethylphenidate-associated hemorrhagic bullous IgA vasculitis

Milan Mahesh, Manju Thomas and Mikael Horissian
JAAD Case Reports, v 71, pp 239-240
01 May 2026
PMID: 42088927
url
https://doi.org/10.1016/j.jdcr.2026.03.011View
Published, Version of Record (VoR) Open CC BY V4.0

Abstract

bullous dermatosis dexmethylphenidate drug reaction IgA vasculitis pediatric vasculitis
IgA vasculitis (IgAV), formerly Henoch–Schönlein purpura, is the most frequent systemic vasculitis of childhood, with an annual incidence of 3 to 27 per 100,000 children.1 Although it can occur at any age, the incidence in adults is very low with over 90% of cases occurring in children. The peak incidence is between the ages of 4 and 6 years.1,2 It has a slight male preponderance. Classic features include palpable purpura, arthralgia, abdominal pain, and renal involvement.1,2 While most cases are self-limited, bullous and necrotic variants are rare and can lead to scarring.3 We present a case of hemorrhagic bullous IgAV temporally associated with dexmethylphenidate use in a pediatric patient with attention deficit hyperactivity disorder (ADHD).

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