Journal article
Diagnosis and Monitoring of Osteoporosis With 18F-Sodium Fluoride PET: An Unavoidable Path for the Foreseeable Future
Seminars in nuclear medicine, v 48(6), pp 535-540
Nov 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The prevalence of metabolic bone diseases particularly osteoporosis and its precursor, osteopenia, continue to grow as serious global health issues today. On a worldwide perspective, 200million people suffer from osteoporosis and in 2005, over 2million fracture incidents were estimated due to osteoporosis in the United States. Currently, osteoporosis and other metabolic bone diseases are evaluated primarily through dual energy X-ray absorptiometry, and rarely by bone biopsy with tetracycline labeling or Technetium-99m (99mTc) based bone scintigraphy. Deficiencies in these methods have prompted the use of more precise methods of assessment. This review highlights the use of 18F-sodium fluoride (NaF) with PET (NaF-PET), NaF-PET/CT, or NaF-PET/MRI in the evaluation of osteoporosis and osteopenia in the lumbar spine and hip. This imaging modality provides a molecular perspective with respect to the underlying metabolic alterations that lead to osseous disorders by measuring bone turnover through standardized uptake values. Its sensitivity and ability to examine the entire skeletal system make it a more superior imaging modality compared to standard structural imaging techniques. Further research is needed to determine its accuracy in reflecting the efficacy of therapeutic interventions in metabolic bone diseases.
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Details
- Title
- Diagnosis and Monitoring of Osteoporosis With 18F-Sodium Fluoride PET: An Unavoidable Path for the Foreseeable Future
- Creators
- Catherine C. Reilly - University of PennsylvaniaWilliam Y. Raynor - University of PennsylvaniaAbigail L. Hong - University of PennsylvaniaDaniel C. Kargilis - University of PennsylvaniaJae S. Lee - University of PennsylvaniaAustin G. Alecxih - University of PennsylvaniaNishtha Gupta - University of PennsylvaniaMarie K. Lim - University of PennsylvaniaAbdullah Al-Zaghal - University of PennsylvaniaThomas J. Werner - University of PennsylvaniaSylvia S. Rhodes - University of PennsylvaniaAbass Alavi - University of PennsylvaniaChamith S. Rajapakse - University of Pennsylvania
- Publication Details
- Seminars in nuclear medicine, v 48(6), pp 535-540
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000449037100008
- Scopus ID
- 2-s2.0-85052734590
- Other Identifier
- 991019350574804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging