Journal article
Diagnosis and management of bronchopulmonary dysplasia
BMJ (Online), v 375, pp n1974-n1974
20 Oct 2021
PMID: 34670756
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
AbstractBronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants and is associated with increased mortality, respiratory morbidity, neurodevelopmental impairment, and increased healthcare costs. In parallel with advances made in the field of neonatal intensive care, the phenotype of BPD has evolved from a fibrocystic disease affecting late preterm infants to one of impaired parenchymal development and dysregulated vascular growth predominantly affecting infants born before 29 weeks’ gestational age. BPD has been shown to have significant lifelong consequences. Adults with BPD have been found to have abnormal lung function tests, reduced exercise tolerance, and may be at increased risk for developing chronic obstructive pulmonary disease. Evidence shows that BPD occurs secondary to genetic-environmental interactions in an immature lung. In this review, we evaluate the various clinical definitions, imaging modalities, and biomarker data that are helpful in making an early diagnosis of BPD. In addition, we evaluate recent evidence about the prevention and treatment of BPD. We discuss the invasive and non-invasive ventilation strategies and pharmacological agents used in the early, evolving, and established phases of BPD.
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Details
- Title
- Diagnosis and management of bronchopulmonary dysplasia
- Creators
- Margaret Gilfillan - Drexel UniversityAnita Bhandari - Children's Hospital of PhiladelphiaVineet Bhandari - Cooper Medical School of Rowan University
- Publication Details
- BMJ (Online), v 375, pp n1974-n1974
- Publisher
- British Medical Journal Publishing Group
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000713709400008
- Scopus ID
- 2-s2.0-85117959457
- Other Identifier
- 991019168281104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics