Journal article
Diagnosis of T-cell lymphoma in body fluids: cytologic features and unusual flow cytometric findings
Analytical and quantitative cytology and histology, v 29(5), pp 333-338
Oct 2007
PMID: 17987814
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To demonstrate the unique morphologic and phenotypic features observed in cases of T-cell lymphomas presenting as effusions.
Cytologic slides and flow cytometric histograms of 8 cases of body fluids with T-cell lymphoma were retrospectively reviewed. Morphologic features, flow cytometric histograms and immunophenotypes of the cells were evaluated.
Three of the 8 cases showed 1 or more of the following: intermediate-to-large cells with an increased nuclear-cytoplasmic ratio, finely granular or vacuolated cytoplasm and round or convoluted vesicular nuclei with a prominent single or multiple nucleoli. Flow cytometric studies of these 3 cases showed an abnormal scatter pattern in the myelomonocytic region of the histograms. Phenotypic analysis revealed variable expression of a T-cell phenotype. The remaining cases showed the conventional morphologic and flow cytometric features of a T-cell lymphoma.
Morphologic alterations of neoplastic T-cells in body fluids can result in a variety of potentially incorrect diagnoses. The unusual flow cytometric histogram can serve as a useful clue for the diagnosis of T-cell lymphoma in body fluids but could be a potential pitfall for a false negative. Detailed cytologic evaluation combined with flow cytometric study can improve diagnostic accuracy.
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Details
- Title
- Diagnosis of T-cell lymphoma in body fluids: cytologic features and unusual flow cytometric findings
- Creators
- Mini G Abraham - Drexel UniversityKimberly A LevinManjula BalasubramanianCorrado MinimoLorenzo M GalindoJ Steve Hou
- Publication Details
- Analytical and quantitative cytology and histology, v 29(5), pp 333-338
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000250322300007
- Scopus ID
- 2-s2.0-35348949611
- Other Identifier
- 991019167937304721
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- Cell Biology