Journal article
Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis
Dermatology practical & conceptual, v 14(1), 2024046
01 Jan 2024
PMID: 38364388
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Recurrent aphthous stomatitis (RAS) is a prevalent ulcerative condition affecting oral mucosa. Objectives: A systematic review and meta-analysis was performed to compare the level of neutrophil to lymphocyte ratio (NLR) between individuals with RAS and those who are healthy. Methods: A systematic search for relevant publications before June 21, 2022, was conducted using Web of Science, PubMed, and Scopus. The results were presented as the standardized mean difference (SMD) with a 95% confidence interval (CI), and a random-effects model was used to calculate pooled effects due to the presence of significant heterogeneity. Quality assessment was performed using the Newcastle-Ottawa scale. Results: Overall, 13 article with were included in the analysis. NLR was higher among patients with RAS compared to healthy controls (SMD = 0.50, 95% CI = -0.20 to 0.79, P = 0.001, I2 = 91.5%). In the subgroup analysis based on the study design, it was found that retrospective studies showed higher levels of NLR in patients with RAS compared to healthy controls (SMD = 0.62, 95% CI= 0.16 to 1.08, P < 0.01), but these results were not applied to prospective studies (SMD = 0.35, 95% CI = -0.03 to 0.74, P < 0.07). Conclusion: Elevated neutrophil to lymphocyte ratio revealed crosstalk between systematic inflammation and RAS.
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Details
- Title
- Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis
- Creators
- Mohammad Javad Rahimi - Shiraz University of Medical SciencesFariba Mirakhori - College Station Medical CenterRebecca Zelmanovich - University of Central FloridaChristina Sedaros - University of FloridaBrandon Lucke-Wold - University of FloridaGersham Rainone - Drexel UniversityArshin Ghaedi - Shiraz University of Medical SciencesShokoufeh Khanzadeh - Tabriz University of Medical Sciences
- Publication Details
- Dermatology practical & conceptual, v 14(1), 2024046
- Publisher
- Mattioli 1885
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Dermatology
- Web of Science ID
- WOS:001196706800020
- Scopus ID
- 2-s2.0-85185771244
- Other Identifier
- 991022202513204721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Dermatology