Journal article
Diagnostic Value of FDG PET/MRI in Females With Pelvic Malignancy—A Systematic Review of the Literature
Frontiers in oncology, v 10, 519440
29 Sep 2020
PMID: 33123460
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hybrid imaging with F-18 fludeoxyglucose positron emission tomography/magnetic resonance imaging (FDG PET/MRI) has increasing clinical applications supplementing conventional ultrasound, CT, and MRI imaging as well as hybrid PET/CT imaging in assessing cervical, endometrial, and ovarian cancer. This article summarizes the existing literature and discusses the emerging role of hybrid PET/MRI in gynecologic malignancies. Thus, far, the published literature on the applications of FDG PET/MRI shows that it can have a significant impact on patient management by improving the staging of the cancers compared with PET/CT, influencing clinical decision and treatment strategy. For disease restaging, current literature indicates that PET/MRI performs equivalently to PET/CT. There appears to be a mild-moderate inverse correlation between standard-uptake-value (SUV) and apparent-diffusion-coefficient (ADC) values, which could be used to predict tumor grading and risk stratification. It remains to be seen as to whether multi-parametric PET/MRI imaging could prove valuable for prognostication and outcome. PET/MRI provides the opportunity for reduced radiation exposure, which is particularly relevant for a young female in need of multiple scans for treatment monitoring and follow-up. Fast acquisition protocols and optimized methods for attenuation correction are still evolving. Major limitations of PET/MRI remains such as suboptimal detection of small pulmonary nodules and lack of utility for radiation treatment planning, which pose an impediment in making PET/MRI a viable one-stop-shop imaging option to compete with PET/CT.
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Details
- Title
- Diagnostic Value of FDG PET/MRI in Females With Pelvic Malignancy—A Systematic Review of the Literature
- Creators
- Nghi Co Nguyen - University of PittsburghSushil Beriwal - University of PittsburghChan-Hong Moon - University of PittsburghNicholas D'Ardenne - , , , ,James M. Mountz - University of PittsburghAlessandro Furlan - University of PittsburghAshok Muthukrishnan - University of PittsburghBalasubramanya Rangaswamy - University of Pittsburgh
- Publication Details
- Frontiers in oncology, v 10, 519440
- Publisher
- Frontiers Media S.A
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000579464600001
- Scopus ID
- 2-s2.0-85093644133
- Other Identifier
- 991021897384704721
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- Web of Science research areas
- Oncology