Journal article
Diagnostic and therapeutic applications of miRNA-based strategies to cancer immunotherapy
Cancer and metastasis reviews, v 37(1), pp 45-53
01 Mar 2018
PMID: 29270700
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cancer immunotherapy has shown impressive clinical results in the last decade, improving both solid and hematologic cancer patients' overall survival. Nevertheless, most of the molecular aspects underlying the response to this approach are still under investigation. miRNAs in particular have been described as regulators of a plethora of different immunologic processes and thus have the potential to be key in the future developments of immunotherapy. In this review, we summarize and discuss the emerging role of miRNAs in the diagnosis and therapeutics of the four principal cancer immunotherapy approaches: immune checkpoint blockade, adoptive cell therapy, cancer vaccines, and cytokine therapy. In particular, this review is focused on potential roles for miRNAs to be adjuvants in soluble factor- and cell-based therapies, with the aim of helping to increase specificity and decrease toxicity, and on the potential for rationally identified miRNA-based diagnostic approaches to aid in precision clinical immunooncology.
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Details
- Title
- Diagnostic and therapeutic applications of miRNA-based strategies to cancer immunotherapy
- Creators
- Gabriele Romano - Drexel University, Pharmacology and PhysiologyLawrence N. Kwong - The University of Texas MD Anderson Cancer Center
- Publication Details
- Cancer and metastasis reviews, v 37(1), pp 45-53
- Publisher
- Springer Nature
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000424229500005
- Scopus ID
- 2-s2.0-85038629066
- Other Identifier
- 991021965770604721
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- Web of Science research areas
- Oncology