Journal article
Diet controls Drosophila follicle stem cell proliferation via Hedgehog sequestration and release
The Journal of cell biology, v 201(5), pp 741-757
27 May 2013
PMID: 23690177
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
healthy diet improves adult stem cell function and delays diseases such as cancer, heart disease, and neurodegeneration. Defining molecular mechanisms by which nutrients dictate stem cell behavior is a key step toward understanding the role of diet in tissue homeostasis. In this paper, we elucidate the mechanism by which dietary cholesterol controls epithelial follicle stem cell (FSC) proliferation in the fly ovary. In nutrient-restricted flies, the transmembrane protein Boi sequesters Hedgehog (Hh) ligand at the surface of Hh-producing cells within the ovary, limiting FSC proliferation. Upon feeding, dietary cholesterol stimulates S6 kinase-mediated phosphorylation of the Boi cytoplasmic domain, triggering Hh release and FSC proliferation. This mechanism enables a rapid, tissue-specific response to nutritional changes, tailoring stem cell divisions and egg production to environmental conditions sufficient for progeny survival. If conserved in other systems, this mechanism will likely have important implications for studies on molecular control of stem cell function, in which the benefits of low calorie and low cholesterol diets are beginning to emerge.
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Details
- Title
- Diet controls Drosophila follicle stem cell proliferation via Hedgehog sequestration and release
- Creators
- Tiffiney R. Hartman - Fox Chase Cancer CenterTodd I. Strochlic - Fox Chase Cancer CenterYingbiao Ji - Fox Chase Cancer CenterDaniel Zinshteyn - Fox Chase Cancer CenterAlana M. O'Reilly - Fox Chase Canc Ctr, Canc Biol Program, Philadelphia, PA 19111 USA
- Publication Details
- The Journal of cell biology, v 201(5), pp 741-757
- Publisher
- Rockefeller Univ Press
- Number of pages
- 17
- Grant note
- Pennsylvania Department of Health (Health Research Formula Funds) C000026964 / Commonwealth of Pennsylvania Ben Franklin Technology Development Authority (Keystone Innovation Starter Kit ) R01GM084947 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P30CA006927 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Bucks County Board of Associates IRG-92-027-16; PF-11-068-01-TBE / American Cancer Society R01HD065800 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) HD065800; CA06927 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Fox Chase Cancer Center Board of Associates
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000319504500011
- Scopus ID
- 2-s2.0-84878598437
- Other Identifier
- 991020837746504721
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- Web of Science research areas
- Cell Biology