Dietary Intake of Methionine, Cysteine, and Protein and Urinary Arsenic Excretion in Bangladesh
Environmental health perspectives, v 117(1), pp 99-104
01 Jan 2009
: 19165394
BACKGROUND: In Bangladesh, millions of people are exposed to arsenic in drinking water; arsenic is associated with increased risk of cancer. Once ingested, arsenic is metabolized via methylation and excreted in urine. Knowledge about nutritional factors affecting individual variation in methylation is limited.
OBJECTIVES: The purpose of this study was to examine associations between intakes of protein, methionine, and cysteine total urinary arsenic in a large population-based sample.
METHODS: The study subjects were 10,402 disease-free residents of Araihazar, Bangladesh, who participated in the Health Effects of Arsenic Longitudinal Study (HEALS). Food intakes were assessed using a validated food frequency questionnaire developed for the study population. Nutrient composition was determined by using the U.S. Department of Agriculture National Nutrient Database for Standard Reference. Generalized estimating equations were used to examine association between total urinary arsenic across quintiles of nutrient intakes while controlling for arsenic exposure from drinking water and other predictors of urinary arsenic.
RESULTS: Greater intakes of protein, methionine, and cysteine were associated with 10-15% greater total urinary arsenic excretion, after controlling for total energy intake, body weight, sex, age, tobacco use, and intake of some other nutrients.
CONCLUSIONS: Given previously reported risks between lower rates of arsenic excretion and increased rates of cancer, these findings support the role of nutrition in preventing arsenic-related disease.
- Dietary Intake of Methionine, Cysteine, and Protein and Urinary Arsenic Excretion in Bangladesh
- Julia E. Heck - Columbia UniversityJeri W. Nieves - Columbia UniversityYu Chen - New York UniversityFaruque Parvez - Columbia UniversityPaul W. Brandt-Rauf - Columbia UniversityJoseph H. Graziano - Columbia UniversityVesna Slavkovich - Columbia UniversityGeoffrey R. Howe - Columbia UniversityHabibul Ahsan - University of Chicago
- Environmental health perspectives, v 117(1), pp 99-104
- Us Dept Health Human Sciences Public Health Science
- 6
- R01CA107431 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01 CA107431; R01 CA102484; R01CA107431; R01CA102484 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P42ES010349 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P30ES09089; P30 ES009089; P42 ES010349; P42ES10349 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Journal article
- English
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- WOS:000262483900036
- 2-s2.0-60749105001
- 991019323667104721
research.portal.fulldisplay.sdgs.intro
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- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology