Journal article
Dietary Polyphenols and Inflammatory Markers in Rural Adult Women in Puno, Peru
The Journal of nutrition, v 155(12), pp 4540-4548
Dec 2025
PMID: 41082979
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dietary polyphenols are bioactive compounds credited with health protection and reducing inflammation. Evidence on their effects is limited in low- and middle-income countries, especially among rural populations.
To evaluate the association between dietary polyphenols intake and markers of inflammation and endothelial adhesion over 12 mo of follow-up among rural adult women participating in the Cardiopulmonary Outcomes and Household Air Pollution randomized controlled trial.
We used data at baseline and 12-mo visit in 100 healthy women aged 25–64 y living in rural communities in Puno, Peru. We assessed dietary intake using 24-h dietary recalls and measured inflammatory cytokines [interleukin (IL)-10, IL-6, IL-1β, C-reactive protein, tumor necrosis factor-α] and endothelial adhesion (vascular cell adhesion protein-1, intercellular adhesion molecule-1) biomarkers in dried blood spots using immunoassay analyses. We quantified polyphenol intake using the Phenol-Explorer database. We used multivariable linear regression to assess the association between changes (12-mo of follow-up minus baseline) in dietary polyphenols intake, and inflammatory and endothelial adhesion markers at 12-mo.
At baseline, mean (±standard deviation) participant age was 49 ± 10 y, mean total polyphenol intake was 335 ± 193 mg/d, and mean phenolic acids intake was 195 ± 80 mg/d. Lower IL-1β concentrations at 12-mo were associated with higher energy-adjusted phenolic acid intake [adjusted mean difference −0.35 pg/mL per mg/d; 95% confidence interval (CI): −0.63, −0.07]. In contrast, higher anti-inflammatory cytokines IL-10 concentrations at 12 mo were associated with higher energy-adjusted intake of stilbenes (0.42 pg/mL per mg/d; 95% CI: 0.18, 0.66) and other polyphenols (0.28 pg/mL per mg/d; 95% CI: 0.10, 0.46).
Higher polyphenol intake, particularly phenolic acids and stilbenes, was associated with an improved anti-inflammatory profile in rural women.
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Details
- Title
- Dietary Polyphenols and Inflammatory Markers in Rural Adult Women in Puno, Peru
- Creators
- Emily P Laveriano-Santos - Centro de Investigación Biomédica en RedCarla Tarazona-Meza - Johns Hopkins UniversityGary Malpartida - PrismaDana B Barr - Emory UniversityKendra N Williams - Johns Hopkins UniversityJosiah L Kephart - Drexel University, Environmental and Occupational HealthLaura Nicolaou - Johns Hopkins UniversityMagdalena Fandiño-Del-Rio - Johns Hopkins UniversitySuzanne Simkovich - Johns Hopkins UniversityMarilu Chiang - PrismaKirsten Koehler - Johns Hopkins UniversityRosa M Lamuela-Raventós - Spanish Biomedical Research Centre in Physiopathology of Obesity and NutritionWilliam Checkley - Johns Hopkins UniversityCardiopulmonary Outcomes and Household Air Pollution (CHAP) trial investigators
- Publication Details
- The Journal of nutrition, v 155(12), pp 4540-4548
- Publisher
- Elsevier Inc
- Number of pages
- 9
- Grant note
- Clean Cooking Alliance of the United Nations Foundation: U01TW010107, U2RTW010114 "Juan de la Cierva-Formacion": UNF-16-810 Ministerio de Ciencia e Innovacion (MICIN): JDC2022-049842 European Union NextGeneration EU/PRTR: MCIN/AEI/10.13039/501100011033 INSA-UBMaria de Maeztu Center of Excellence: MCIN/AEI/10.13039/501100011033, CEX2021-001234-M, CEX2023-0001290-S Generalitat de Catalunya through the CERCA Program
U01TW010107 and U2RTW010114 (MPIs: Checkley, Gonzales, Naeher, Steenland) . Furthermore, the trial received partial support from the Clean Cooking Alliance of the United Nations Foundation (UNF-16-810, PI: Checkley) . EPL-S was supported by the "Juan de la Cierva-Formacion" grant (JDC2022-049842) funded by the Ministerio de Ciencia e Innovacion (MICIN) (MCIN/AEI/10.13039/501100011033) and, by European Union NextGeneration EU/PRTR. INSA-UB is a Maria de Maeztu Center of Excellence (grant CEX2021-001234-M both funded by MICIN/AEI/FEDER, UE) . ISGlobal was supported from the grant CEX2023-0001290-S funded by MCIN/AEI/10.13039/501100011033, and from the Generalitat de Catalunya through the CERCA Program. CT-M was supported by the D43-funded Fogarty Research training in Chronic, Non-Communicable Respiratory Diseases in Peru (PulmPERU) training grant (D43TW011502) .r U01TW010107 and U2RTW010114 (MPIs: Checkley, Gonzales, Naeher, Steenland) . Furthermore, the trial received partial support from the Clean Cooking Alliance of the United Nations Foundation (UNF-16-810, PI: Checkley) . EPL-S was supported by the "Juan de la Cierva-Formacion" grant (JDC2022-049842) funded by the Ministerio de Ciencia e Innovacion (MICIN) (MCIN/AEI/10.13039/501100011033) and, by European Union NextGeneration EU/PRTR. INSA-UB is a Maria de Maeztu Center of Excellence (grant CEX2021-001234-M both funded by MICIN/AEI/FEDER, UE) . ISGlobal was supported from the grant CEX2023-0001290-S funded by MCIN/AEI/10.13039/501100011033, and from the Generalitat de Catalunya through the CERCA Program. CT-M was supported by the D43-funded Fogarty Research training in Chronic, Non-Communicable Respiratory Diseases in Peru (PulmPERU) training grant (D43TW011502) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel FIRST (Center for Firefighter Injury Research and Safety Trends); Urban Health Collaborative; Environmental and Occupational Health
- Web of Science ID
- WOS:001634458400001
- Scopus ID
- 2-s2.0-105021009667
- Other Identifier
- 991022123362904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Nutrition & Dietetics