Journal article
Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA)
The American journal of clinical nutrition, v 88(5), pp 1405-1412
01 Nov 2008
PMID: 18996878
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Telomere length reflects biological aging and may be influenced by environmental factors, including those that affect inflammatory processes.
Objective: With data from 840 white, black, and Hispanic adults from the Multi-Ethnic Study of Atherosclerosis, we studied cross-sectional associations between telomere length and dietary patterns and foods and beverages that were associated with markers of inflammation.
Design: Leukocyte telomere length was measured by quantitative polymerase chain reaction. Length was calculated as the amount of telomeric DNA (T) divided by the amount of a single-copy control DNA (S) (T/S ratio). Intake of whole grains, fruit and vegetables, low-fat dairy, nuts or seeds, nonfried fish, coffee, refined grains, fried foods, red meat, processed meat, and sugar-sweetened soda were computed with responses to a 120-item food-frequency questionnaire completed at baseline. Scores on 2 previously defined empirical dietary patterns were also computed for each participant.
Results: After adjustment for age, other demographics, lifestyle factors, and intakes of other foods or beverages, only processed meat intake was associated with telomere length. For every 1 serving/d greater intake of processed meat, the T/S ratio was 0.07 smaller (beta +/- SE: -0.07 +/- 0.03, P = 0.006). Categorical analysis showed that participants consuming >= 1 serving of processed meat each week had 0.017 smaller T/S ratios than did nonconsumers. Other foods or beverages and the 2 dietary patterns were not associated with telomere length.
Conclusions: Processed meat intake showed an expected inverse association with telomere length, but other diet features did not show their expected associations. Am J Clin Nutr 2008; 88: 1405-12.
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Details
- Title
- Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA)
- Creators
- Jennifer A. Nettleton (Corresponding Author) - The University of Texas Health Science Center at HoustonAna Diez-Roux - University of MichiganNancy S. Jenny - University of VermontAnnette L. Fitzpatrick - University of WashingtonDavid R. Jacobs - Hennepin County Library
- Publication Details
- The American journal of clinical nutrition, v 88(5), pp 1405-1412
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- M01-RR00645 / General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) MacArthur Foundation N01-HC-95159; N01-HC-95166; N01-HC-95169 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000260770600030
- Scopus ID
- 2-s2.0-55849111507
- Other Identifier
- 991020111619304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Nutrition & Dietetics