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Journal article
Difference by sex but not by race/ethnicity in the visceral adipose tissue-depressive symptoms association: The Multi-Ethnic Study of Atherosclerosis
Psychoneuroendocrinology, v 47
Sep 2014
PMID: 25001957
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prior studies have investigated the association of clinical depression and depressive symptoms with body weight (i.e. body mass index (BMI) and waist circumference), but few have examined the association between depressive symptoms and intra-abdominal fat. Of these a limited number assessed the relationship in a multi-racial/ethnic population.
Using data on 1017 men and women (45–84 years) from the Multi-Ethnic Study of Atherosclerosis (MESA) Body Composition, Inflammation and Cardiovascular Disease Study, we examined the cross-sectional association between elevated depressive symptoms (EDS) and CT-measured visceral fat mass at L2–L5 with multivariable linear regression models. EDS were defined as a Center for Epidemiological Studies Depression score ≥16 and/or anti-depressant use. Covariates included socio-demographics, inflammatory markers, health behaviors, comorbidities, and body mass index (BMI). Race/ethnicity (Whites [referent group], Chinese, Blacks and Hispanics) and sex were also assessed as potential modifiers.
The association between depressive symptoms and visceral fat differed significantly by sex (p=0.007), but not by race/ethnicity. Among men, compared to participants without EDS, those with EDS had greater visceral adiposity adjusted for BMI and age (difference=122.5cm2, 95% CI=34.3, 210.7, p=0.007). Estimates were attenuated but remained significant after further adjustment by socio-demographics, inflammatory markers, health behaviors and co-morbidities (difference=94.7cm2, 95% CI=10.5, 178.9, p=0.028). Among women, EDS was not significantly related to visceral adiposity in the fully adjusted model.
Sex, but not race/ethnicity, was found to modify the relationship between EDS and visceral fat mass. Among men, a significant positive association was found between depressive symptoms and visceral adiposity. No significant relationship was found among women.
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Details
- Title
- Difference by sex but not by race/ethnicity in the visceral adipose tissue-depressive symptoms association: The Multi-Ethnic Study of Atherosclerosis
- Creators
- Rosemay A. Remigio-Baker - University of California San DiegoMatthew A. Allison - University of California San DiegoPamela J. Schreiner - University of MinnesotaMoyses Szklo - Bloomberg (United States)Rosa M. Crum - Johns Hopkins UniversityJeannie-Marie Leoutsakos - Johns Hopkins UniversityManuel Franco - Bloomberg (United States)Mercedes R. Carnethon - Northwestern UniversityJennifer A. Nettleton - The University of Texas at AustinMahasin S. Mujahid - University of California, BerkeleyAna V. Diez Roux - University of Michigan School of Public Health, Ann Arbor, MI, USANicole Jensky - University of California San DiegoSherita H. Golden - Johns Hopkins University
- Publication Details
- Psychoneuroendocrinology, v 47
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000339694500009
- Scopus ID
- 2-s2.0-84903692087
- Other Identifier
- 991020111974004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Neurosciences
- Psychiatry