Journal article
Differences between young and aged mice in suceptibility to Friend virus
Mechanisms of ageing and development, v 73(2), pp 145-155
1994
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Friend virus (FV) is a murine leukemia virus that infects progenitor red blood cells and causes an erythroleukemia in susceptible mouse strains, resulting in splenomegaly. Several genetic loci of the host have been identified that affect erythroleukemia development, differentiation status of target cells and virus replication. Since age may change expression of these loci, age may affect FV disease. To explore this possibility, FV expression in four genetically diverse strains of mice of different ages was examined. Extent of viral replication and of disease were evaluated by measuring spleen focus forming units (SFFU), spleen weight and reverse transcriptase (RT) activity in target organs. Young DBA/2 and (C57BL/6 × DBA/2)F
1 mice exhibited a greater level of virus expression than their aged counterparts in all parameters investigated. Young CBA/Ca mice had slightly higher spleen weights and SFFU values than aged CBA/Ca mice, but a definitive age-related change was not observed in the RT activity of the target organs. C57BL/6 mice, which are genetically resistant to the development of FV-induced erythroleukemia, exhibited a limited degree of virus replication that was not effected by the age of the animal. Our results indicate that the age of the mouse, as well as the genetic background, can contribute to the level of susceptibility to FV.
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Details
- Title
- Differences between young and aged mice in suceptibility to Friend virus
- Creators
- Deneen R. Stewart - Drexel UniversityDawn A. Kirschmann - Drexel UniversityKenneth J. Blank - Hahnemann University HospitalDonna M. Murasko - Drexel University
- Publication Details
- Mechanisms of ageing and development, v 73(2), pp 145-155
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1994NC54800006
- Scopus ID
- 2-s2.0-0028264820
- Other Identifier
- 991020950673104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology