Journal article
Differences in congenital anomalies in unassisted conception vs. in vitro fertilization in dichorionic-diamniotic twin pregnancies
Fertility and sterility, v 125(5)
31 Jan 2026
PMID: 41621791
Abstract
The aim of this study was to evaluate the incidence of congenital anomalies in dichorionic-diamniotic twins conceived with in vitro fertilization (IVF) vs. unassisted conception pregnancies in a large geographically diverse population.
This is a secondary analysis of data from a retrospective cohort study of twin pregnancies seen at 17 centers between December, 2011–February, 2020.
This study included dichorionic-diamniotic twins conceived unassisted, or by in vitro fertilization.
The exposure group is dichorionic-diamniotic twins conceived with IVF.
The primary outcome was presence of a congenital anomaly. Neonates with an abnormal newborn examination were evaluated for having a major or minor congenital anomaly and the major anomalies were further classified by organ system (cardiac, renal/genitourinary, gastrointestinal, and musculoskeletal).
Of the 968 dichorionic-diamniotic twin pregnancies included, 521 (53.8%) were conceived with IVF and 447 (46.2%) were conceived unassisted. Congenital anomalies were found in 70 pregnancies (7.23%). Of those, 37 were found in pregnancies conceived by IVF (52.9%) vs. 33 unassisted conception pregnancies (47.1). There were no significant differences between IVF and unassisted conception pregnancies for major anomalies or minor anomalies.
In this large cohort of twin pregnancies, there is no significant difference in the incidence of anomalies for dichorionic-diamniotic twin pregnancies conceived by IVF vs. unassisted conception pregnancies.
Metrics
2 Record Views
Details
- Title
- Differences in congenital anomalies in unassisted conception vs. in vitro fertilization in dichorionic-diamniotic twin pregnancies
- Creators
- Hannah S. Foster - University of PennsylvaniaMeaghan G. McCabe - University of PennsylvaniaNathaniel Koelper - University of PennsylvaniaBryann Bromely - Massachusetts General HospitalStephen Chasen - Cornell UniversityMelissa L. Russo - Women & Infants Hospital of Rhode IslandAshely S. Roman - Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, New York University Langone Health, New York, New YorkMeghana A. Limaye - NYU Langone HealthAngela C. Ranzini - MetroHealthCaitlin Clifford - University of MichiganJoseph R. Biggio - Section of Maternal Fetal Medicine, Women's Service Line, Department of Obstetrics and Gynecology, Ochsner Health, New Orleans, LouisianaAkela Subramaniam - University of Alabama at BirminghamAvinash S. Patil - East Carolina UniversitySamantha Wedd - Franciscan University of SteubenvilleJessica M. Page - Intermountain HealthcareSara Nicholas - Main Line HealthJay Idler - Drexel University, Obstetrics and GynecologyRashmi Rao - University of California, Los AngelesAmber Crowder - Centura, Littleton, ColoradoRaj Shree - University of WashingtonGraham McLennan - LabCorp, San Diego, CaliforniaLorraine Dugoff - University of Pennsylvania
- Publication Details
- Fertility and sterility, v 125(5)
- Publisher
- Elsevier Inc
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Obstetrics and Gynecology
- Web of Science ID
- WOS:001772904600001
- Scopus ID
- 2-s2.0-105031820390
- Other Identifier
- 991022165638604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output