Journal article
Differences in the immune response during the acute phase of E-55+ murine leukemia virus infection in progressor BALB and long term nonprogressor C57BL mice
The Journal of immunology (1950), v 161(1), pp 17-26
01 Jul 1998
PMID: 9647202
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
E-55+ murine leukemia virus infection of both progressor (BALB) and long term nonprogressor (C57BL) mouse strains is characterized by an acute and a persistent phase of infection. During the acute phase, progressor strains require CD8+ T cells to decrease virus burden, whereas the long term nonprogressor strains do not. In the present studies the immune response in BALB and C57BL mice during the acute phase of E-55+ murine leukemia virus infection was examined. The results demonstrate that BALB mice produce both IL-4 and IFN-gamma, in contrast to C57BL mice, which produce only IFN-gamma. In BALB mice, IL-4 production results in the absolute requirement for CD8+ T cells to reduce the virus burden during the acute phase of infection. The anti-virus immune response in these mice is IFN-gamma dependent. On the other hand, C57BL mice do not produce IL-4 and, in the absence of both CD8+ T cells and IFN-gamma, still generate an effective anti-virus immune response. Genetic studies suggest that these distinct immune responses are regulated by more than one non-MHC-linked gene. Two candidate regions that may encode this gene(s), located on chromosomes 7 and 19, respectively, were identified by recombinant inbred strain linkage analysis.
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Details
- Title
- Differences in the immune response during the acute phase of E-55+ murine leukemia virus infection in progressor BALB and long term nonprogressor C57BL mice
- Creators
- V Panoutsakopoulou - Department of Pathology, Allegheny University of the Health Sciences, Philadelphia, PA 19102, USAC S LittleT G SieckE P BlankenhornK J Blank
- Publication Details
- The Journal of immunology (1950), v 161(1), pp 17-26
- Publisher
- United States
- Grant note
- CA65389 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000074302700004
- Scopus ID
- 2-s2.0-7144242345
- Other Identifier
- 991014877902104721
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- Web of Science research areas
- Immunology