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Differences in the role of black race and stroke risk factors for first vs. recurrent stroke
Journal article   Open access   Peer reviewed

Differences in the role of black race and stroke risk factors for first vs. recurrent stroke

George Howard, Brett M Kissela, Dawn O Kleindorfer, Leslie A McClure, Elsayed Z Soliman, Suzanne E Judd, J David Rhodes, Mary Cushman, Claudia S Moy, Kara A Sands, …
Neurology, v 86(7), pp 637-642
16 Feb 2016
DOI: https://doi.org/10.1212/WNL.0000000000002376
PMID: 26791153
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1212/wnl.0000000000002376View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open
url
https://doi.org/10.1212/WNL.0000000000002376View
Published, Version of Record (VoR) Open

Abstract

African Americans Age Factors Aged European Continental Ancestry Group Female Follow-Up Studies Humans Longitudinal Studies Male Middle Aged Recurrence Risk Factors Stroke - ethnology
To assess whether black race and other cerebrovascular risk factors have a differential effect on first vs. recurrent stroke events. Estimate the differences in the magnitude of the association of demographic (age, back race, sex) or stroke risk factors (hypertension, diabetes, cigarette smoking, atrial fibrillation, left ventricular hypertrophy, or heart disease) for first vs. recurrent stroke from a longitudinal cohort study of 29,682 black or white participants aged 45 years and older. Over an average 6.8 years follow-up, 301 of 2,993 participants with a previous stroke at baseline had a recurrent stroke, while 818 of 26,689 participants who were stroke-free at baseline had a first stroke. Among those stroke-free at baseline, there was an age-by-race interaction (p = 0.0002), with a first stroke risk 2.70 (95% confidence interval: 1.86-3.91) times greater for black than white participants at age 45, but no racial disparity at age 85 (hazard ratio = 0.91; 95% confidence interval: 0.70-1.18). In contrast, there was no evidence of a higher risk of recurrent stroke at any age for black participants (p > 0.05). The association of traditional stroke risk factors was generally similar for first and recurrent stroke. The association of age and black race differs substantially on first vs. recurrent stroke risk, with risk factors playing a similar role.

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54 citations in Web of Science
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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
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