Journal article
Differences in urethral dosimetry between CT and MR imaging in multichannel vaginal cylinder brachytherapy
Brachytherapy, v 16(5), pp 964-967
Sep 2017
PMID: 28694115
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In image-based brachytherapy (IBBT), the dosimetry of small structures may be particularly sensitive to changes in contouring between imaging modalities. We therefore sought to characterize differences in urethral dosimetry in vaginal brachytherapy based on contouring on MRI vs. CT.
We retrospectively identified our most recent 15 patients treated with intracavitary brachytherapy for distal vaginal malignancies. On T2-weighted MRI, both the lumen and urethral wall were contoured. On CT, the urethral lumen alone was contoured, as the wall is indistinguishable from surrounding tissue. High-dose-rate (HDR) IBBT plans were generated for all patients.
Mean urethral volume was higher on MRI than CT at 3.7 cc vs. 1.1 cc (p < 0.0005). As a result, there were statistically significant increases on MRI in D0.1cc and D0.5cc, as well as EQD2 D0.1cc and EQD2 D0.5cc when applied to a full course of treatment (45 Gy EBRT + 25 Gy IBBT).
We have quantified the expected differences in urethral volume and dosimetry when contoured on MRI vs. CT. Inclusion of the urethral wall on MRI, with its average thickness of 2.2 mm, likely more accurately reflects the true organ at risk and results in an increase in reported dose compared to CT.
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Details
- Title
- Differences in urethral dosimetry between CT and MR imaging in multichannel vaginal cylinder brachytherapy
- Creators
- Katherine S. Chen - University of PittsburghScott M. Glaser - UPMC Hillman Cancer CenterHayeon Kim - UPMC Hillman Cancer CenterSushil Beriwal - UPMC Hillman Cancer Center
- Publication Details
- Brachytherapy, v 16(5), pp 964-967
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000411920100007
- Scopus ID
- 2-s2.0-85021741404
- Other Identifier
- 991021897372104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging