Journal article
Differential Effects of Injury Severity on Cognition and Cellular Pathology after Contusive Brain Trauma in the Immature Rat
Journal of neurotrauma, v 28(2)
01 Feb 2011
PMID: 21091272
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although diffuse brain damage has been suggested to be the predominant predictor of neurological morbidity following closed head injury in infants and children, the presence of contusions also predicts long-term neurobehavioral dysfunction. Contusive brain trauma in the 17-day-old rat resulted in neurodegeneration and caspase activation in the cortex at 1 day, and in the thalamus at 3 days post-injury, and to a greater extent following a deeper impact. Cortical tissue loss in the 4-mm impact group was significantly greater than that in the 3-mm impact group (
p
< 0.05), and exhibited a time-dependent increase over the first 3 weeks post-injury. Traumatic axonal injury was observed in the white matter tracts below the site of impact at 1 day, and in the corpus callosum at 3 days, to a greater extent following 4-mm impact. In contrast, cellular caspase-3 activation in these white matter tracts was only observed at 24 h post-injury and was not affected by impact depth. Similarly, neurodegeneration and caspase activation in the hippocampus was restricted to the dentate gyrus and occurred to a similar extent in both injured groups. Only the 4-mm impact group exhibited learning deficits in the first week (
p
< 0.0001) that was sustained until the third week post-injury (
p
< 0.0001), while deficits in the 3-mm impact group were seen only at 3 weeks post-injury (
p
< 0.02). These observations demonstrate that increasing severity of injury in immature animals does not uniformly increase the extent of cellular damage, and that the progression of tissue damage and behavioral deficits varies as a function of injury severity.
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Details
- Title
- Differential Effects of Injury Severity on Cognition and Cellular Pathology after Contusive Brain Trauma in the Immature Rat
- Creators
- Jimmy W Huh - 1Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaAshley G Widing - 2Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PennsylvaniaRamesh Raghupathi - 2Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania
- Publication Details
- Journal of neurotrauma, v 28(2)
- Publisher
- Mary Ann Liebert, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000287234700008
- Scopus ID
- 2-s2.0-79951684276
- Other Identifier
- 991014877680404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Critical Care Medicine
- Neurosciences