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Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise
Journal article   Open access   Peer reviewed

Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise

Danielle Bernardes, Onésia Cristina Oliveira-Lima, Thiago Vitarelli da Silva, Camila Cristina Fraga Faraco, Hércules Ribeiro Leite, Maria Aparecida Juliano, Daniel Moreira dos Santos, John R. Bethea, Roberta Brambilla, Jacqueline M. Orian, …
Journal of neuroimmunology, v 264(01-Feb)
15 Nov 2013
DOI: https://doi.org/10.1016/j.jneuroim.2013.08.014
PMID: 24054000
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://www.jni-journal.com/article/S0165572813002373/pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1016/j.jneuroim.2013.08.014View
Published, Version of Record (VoR) Open

Abstract

BDNF Exercise Experimental autoimmune encephalomyelitis Intravital microscopy Neuroinflammation Neuroprotection
The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised. •We investigated the neuroimmunophysiological effects of exercise in EAE.•Prior swimming attenuated clinical presentation of EAE from onset to peak disease.•Prior swimming did not alter CNS recruitment of leukocytes in EAE.•Prior swimming altered cytokines levels in the brain and spinal cord in EAE mice.•Prior swimming increased BDNF levels in the brain and spinal cord in peak EAE mice.

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78 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Immunology
Neurosciences
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