Journal article
Differential effects of glucocorticoid and mineralocorticoid antagonism on anxiety behavior in mild traumatic brain injury
Behavioural brain research, v 312, pp 362-365
01 Oct 2016
PMID: 27363926
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mild traumatic brain injuries (TBIs) comprise three-quarters of all TBIs occurring in the United States annually, and psychological symptoms arising from them can last years after injury. One commonly observed symptom following mild TBI is generalized anxiety. Most mild TBIs happen in stressful situations (sports, war, domestic violence, etc.) when glucocorticoids are elevated in the brain at the time of impact, and glucocorticoids have negative effects on neuronal health following TBI. Therefore, blocking glucocorticoid receptors might prevent emergence of anxiety symptoms post-injury. Adult male rats received mifepristone (20 mg/kg) or spironolactone (50 mg/kg) to block glucocorticoid and mineralocorticoid receptors, respectively, 40 min prior to being exposed to acute social defeat stress followed immediately by mild TBI. In defeated rats with concomitant mild TBI, mifepristone restored time spent in the open arms of an elevated plus maze to control levels, demonstrating for the first time that glucocorticoid receptors play a critical role in the development of anxiety after mild TBI. Future treatments could target these receptors, alleviating anxiety as a major side effect in victims of mild TBI sustained in stressful situations. (C) 2016 Elsevier B.V. All rights reserved.
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Details
- Title
- Differential effects of glucocorticoid and mineralocorticoid antagonism on anxiety behavior in mild traumatic brain injury
- Creators
- Laura C. Fox - University of South DakotaDaniel R. Davies - University of South DakotaJamie L. Scholl - University of South DakotaMichael J. Watt - University of South DakotaGina L. Forster - University of South Dakota
- Publication Details
- Behavioural brain research, v 312, pp 362-365
- Publisher
- Elsevier
- Number of pages
- 4
- Grant note
- W81XWH-10-1-0578 / United States Department of Defense University of South Dakota Medical Student Summer Science Research Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000381950100040
- Scopus ID
- 2-s2.0-84978036302
- Other Identifier
- 991022195048404721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
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- Web of Science research areas
- Behavioral Sciences
- Neurosciences