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Differential effects of stimulatory factors on natural killer cell activities of young and aged mice
Journal article   Open access   Peer reviewed

Differential effects of stimulatory factors on natural killer cell activities of young and aged mice

Shoko Nogusa, Donna M Murasko and Elizabeth M Gardner
The journals of gerontology. Series A, Biological sciences and medical sciences, v 67(9), pp 947-954
Sep 2012
DOI: https://doi.org/10.1093/gerona/gls079
PMID: 22454373
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1093/gerona/gls079View
Published, Version of Record (VoR) Open

Abstract

Adjuvants, Immunologic - pharmacology Pore Forming Cytotoxic Proteins - metabolism Granzymes - metabolism Mice, Inbred C57BL Interleukin-15 - pharmacology Aging - immunology Animals Interleukin-2 - pharmacology Killer Cells, Natural - immunology Interleukin-18 - pharmacology Killer Cells, Natural - drug effects Mice Killer Cells, Natural - metabolism In Vitro Techniques Cytotoxicity, Immunologic - drug effects Cytokines - pharmacology Interferon-gamma - biosynthesis Interleukin-12 - pharmacology
Age-associated influences on natural killer (NK) cell functions following cytokine stimulation were examined in splenocytes from C57BL/6 mice. NK cells of both young and aged mice exhibited significantly increased: interferon-γ production after interleukin (IL)-12 or IL-15 alone or any combination of IL-12, IL-18, and IL-2; cytotoxicity after IL-2 or IL-15; and granzyme B expression after IL-15. The only significant age-associated differences were observed in interferon-γ production after IL-15 or IL-12 + 18 + 2 and in granzyme B expression following IL-2 or IL-15. Perforin expression did not increase following stimulation; however, NK cells from aged mice expressed significantly higher levels than young mice. These results underscore the complexity of the cytokine-induced functional activities of NK cells and illustrate the differential response of NK cells from young and aged mice to cytokine stimulation.

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Collaboration types
Domestic collaboration
Web of Science research areas
Geriatrics & Gerontology
Gerontology
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