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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Differential longitudinal decline on the Mini-Mental State Examination in frontotemporal lobar degeneration and Alzheimer disease
Alzheimer disease and associated disorders, v 27(4), pp 310-315
Oct 2013
PMID: 23314064
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To examine how phenotype affects longitudinal decline on the Mini-Mental State Examination (MMSE) in patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD).
The MMSE is the most commonly administered assessment for dementia severity; however, the effects of phenotype on longitudinal MMSE performance in FTLD and AD have not been extensively studied.
Data from 185 patients diagnosed with AD (n=106) and 3 FTLD (n=79) phenotypes [behavioral variant frontotemporal dementia (bvFTD), nonfluent agrammatic variant of primary progressive aphasia (nfaPPA), and semantic variant PPA (svPPA)] were collected for up to 52 months since initial evaluation.
Differential rates of decline were noted in that MMSE scores declined more precipitously for AD and svPPA compared with bvFTD and nfaPPA patients (P=0.001). The absolute 4-year MMSE decline given median baseline MMSE for bvFTD [14.67; 95% confidence interval (CI), 14.63-14.71] and nfaPPA (11.02; 95% CI, 10.98-11.06) were lower than svPPA (22.32; 95% CI, 22.29-22.34) or AD (22.24; 95% CI, 22.22-22.26).
These data suggest that within-group AD and FTLD phenotypes present distinct patterns of longitudinal decline on the MMSE. MMSE may not be adequately sensitive to track disease progression in some phenotypes of FTLD.
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Details
- Title
- Differential longitudinal decline on the Mini-Mental State Examination in frontotemporal lobar degeneration and Alzheimer disease
- Creators
- Kay See Tan - Cancer Research And BiostatisticsDavid J Libon - Drexel UniversityKatya Rascovsky - University of PennsylvaniaMurray Grossman - University of PennsylvaniaSharon X Xie - Cancer Research And Biostatistics
- Publication Details
- Alzheimer disease and associated disorders, v 27(4), pp 310-315
- Publisher
- Lippincott
- Grant note
- R01 NS044266 / NINDS NIH HHS P01 AG032953 / NIA NIH HHS P30 AG010124 / NIA NIH HHS AG-10124 / NIA NIH HHS AG-32953 / NIA NIH HHS AG-17586 / NIA NIH HHS NS-44266 / NINDS NIH HHS AG-15116 / NIA NIH HHS P50 NS053488 / NINDS NIH HHS P01 AG017586 / NIA NIH HHS NS-53488 / NINDS NIH HHS R01 AG015116 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000327742800003
- Scopus ID
- 2-s2.0-84888136194
- Other Identifier
- 991021901012404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Pathology