Journal article
Differential modulatory effects of norepinephrine on synaptically driven responses of layer V barrel field cortical neurons
Brain research, v 868(1), pp 39-47
2000
PMID: 10841886
Abstract
The effects of norepinephrine (NE) and the alpha-1 agonist phenylephrine (PE) on synaptically evoked responses of electrophysiologically identified pyramidal neurons in layer V of rat somatosensory cortex were studied in brain slices using intracellular recording techniques. When added to the bathing medium NE (10 μM) tended to increase the synaptic responsiveness of regular spiking neurons and decrease the responsiveness of intrinsic burst neurons. NE had mixed effects on layer V cells which were characterized as intermediate types between regular spiking and intrinsic burst neurons. PE exerted a similar spectrum of actions on layer V cortical neurons. For both adrenergic agents the greatest facilitating effect was observed on responses to low intensity synaptic stimulation. These results suggest that NE exerts different modulatory actions on different electrophysiologically-defined classes of layer V sensory cortical neurons.
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Details
- Title
- Differential modulatory effects of norepinephrine on synaptically driven responses of layer V barrel field cortical neurons
- Creators
- Barry D WaterhouseRobert MouradianFrancis M SesslerRick C.S Lin
- Publication Details
- Brain research, v 868(1), pp 39-47
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; [Retired Faculty]
- Web of Science ID
- WOS:000087780500005
- Scopus ID
- 2-s2.0-0034674572
- Other Identifier
- 991014877881904721
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- Web of Science research areas
- Neurosciences