Journal article
Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains
Cellular immunology, v 110(2)
1987
PMID: 2446778
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Abstract
Experimental allergic orchitis (EAO) and experimental allergic encephalomyelitis (EAE) are animal models of organ-specific autoimmune disease. In this study, BALB/cByJ and BALB/ cAnNCr mice were susceptible to both autoimmune diseases whereas BALB/cJ subline mice were resistant. Disease resistance in BALB/cJ mice did not appear to be a reflection of either (i) a nonspecific generalized impairment of cellular immunity or (ii) an alteration in the phenotypic expression of
Bordetella pertussis-induced histamine sensitization, a phenotype which has been shown to be associated with susceptibility to both diseases. Susceptibility to both EAE and EAO was inherited as a dominant trait in F
1 hybrid animals. Segregation analysis in a (BALB/cByJ × BALB/cJ) × BALB/cJ backcross population suggested that disease resistance may be associated with a single genotypic difference in a common regulatory gene affecting susceptibility to both diseases. Linkage analysis of the backcross population failed to demonstrate an association of disease resistance with the mutant
raf-I
b allele carried by BALB/cJ mice. The results of these studies support previous observations that multiple genotypic differences may in fact exist in mice of the BALB/cJ subline and that such differences play a significant role in the genetic control of susceptibility to EAE and EAO.
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Details
- Title
- Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains
- Creators
- Cory Teuscher - University of PennsylvaniaElizabeth P. Blankenhorn - University of PennsylvaniaWilliam F. Hickey - Hahnemann University Hospital
- Publication Details
- Cellular immunology, v 110(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1987L433600010
- Scopus ID
- 2-s2.0-0023621978
- Other Identifier
- 991019184090404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Immunology