Journal article
Differential tolerance to the effects of chlordiazepoxide on unpunished and punished operant responding following chronic treatment
Pharmacology, biochemistry and behavior, v 53(3), pp 593-601
01 Mar 1996
PMID: 8866960
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Differential development of tolerance to the effects of benzodiazepines (BZs) is a common clinical phenomenon. To examine whether the development of tolerance to the response-suppressant and antipunishment effects of BZs were differentially regulated in animals, male Sprague-Dawley rats were treated chronically with either the BZ receptor agonist Chlordiazepoxide (CDP, 25 mg/kg, IP b.i.d.) or saline for 15 weeks and examined under a multiple schedule of operant behavior. Chronic administration of CDP produced tolerance to its suppressive effects on unpunished responding (RI 80 s) but no tolerance to its enhancing effects on punished responding. This conclusion is supported by three observations. First, repeated priming with CDP produced tolerance to its response-suppressive effects in the RI 80-s schedule and revealed increases in punished responding. Second, baseline levels for punished responding remained elevated over the 15-week treatment period. Third, tolerance developed to the response-suppressant effects of CDP under the RI 80-s schedule, as indicated by a sixfold shift to the right in the dose-response curves for rats treated chronically with CDP when compared to saline-treated controls. However, tolerance did not develop to the antipunishment effects of CDP, as indicated by no differences in the dose-response curves for punished responding. Discontinuation of chronic treatment disrupted unpunished responding only on the first day, and reversed the increase in punished responding. Taken together, these results indicate that differential regulation occurs for the development of tolerance to the response-suppressant and antipunishment effects of BZs.
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Details
- Title
- Differential tolerance to the effects of chlordiazepoxide on unpunished and punished operant responding following chronic treatment
- Creators
- Jed S. Shumsky - Boston UniversityIrwin Lucki - University of Pennsylvania
- Publication Details
- Pharmacology, biochemistry and behavior, v 53(3), pp 593-601
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1996TX84500017
- Scopus ID
- 2-s2.0-0029866868
- Other Identifier
- 991020531976304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy