Journal article
Differentiation of Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia Using qEEG/ERP-Based Cognitive Testing and Volumetric MRI in an Outpatient Specialty Memory Clinic
JOURNAL OF ALZHEIMERS DISEASE, v 90(4), p1761
2022
PMID: 36373320
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Distinguishing between subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia in a scalable, accessible way is important to promote earlier detection and intervention. Objective: We investigated diagnostic categorization using an FDA-cleared quantitative electroencephalographic/eventrelated potential (qEEG/ERP)-based cognitive testing system (eVox (R) by Evoke Neuroscience) combined with an automated volumetric magnetic resonance imaging (vMRI) tool (Neuroreader (R) by Brainreader). Methods: Patients who self-presented with memory complaints were assigned to a diagnostic category by dementia specialists based on clinical history, neurologic exam, neuropsychological testing, and laboratory results. In addition, qEEG/ERP (n = 161) and quantitative vMRI (n = 111) data were obtained. A multinomial logistic regression model was used to determine significant predictors of cognitive diagnostic category (SCD, MCI, or dementia) using all available qEEG/ERP features and MRI volumes as the independent variables and controlling for demographic variables. Area under the Receiver Operating Characteristic curve (AUC) was used to evaluate the diagnostic accuracy of the prediction models. Results: The qEEG/ERP measures of Reaction Time, Commission Errors, and P300b Amplitude were significant predictors (AUC= 0.79) of cognitive category. Diagnostic accuracy increased when volumetric MRI measures, specifically left temporal lobe volume, were added to the model (AUC= 0.87). Conclusion: This study demonstrates the potential of a primarily physiological diagnostic model for differentiating SCD, MCI, and dementia using qEEG/ERP-based cognitive testing, especially when combined with volumetric brain MRI. The accessibility of qEEG/ERP and vMRI means that these tools can be used as adjuncts to clinical assessments to help increase the diagnostic certainty of SCD, MCI, and dementia.
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Details
- Title
- Differentiation of Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia Using qEEG/ERP-Based Cognitive Testing and Volumetric MRI in an Outpatient Specialty Memory Clinic
- Publication Details
- JOURNAL OF ALZHEIMERS DISEASE, v 90(4), p1761
- Publisher
- IOS PRESS; AMSTERDAM
- Grant note
- This research has benefited from the clinical infrastructure of the Pacific Brain Health Center (PBHC) at which all qEEG assessments were completed. We thank the PBHC clinical staff members, including Practice Manager Kyrsten Cardenas, who supported the care and assessments conducted for both care management and research purposes. We also thank the Pacific Neuroscience Institute Foundation team, including Vice President Melissa Coleman, Esq., and Office Manager/Executive Assistant Danielle Wozniak, BS. We are also grateful to the clinical research infrastructure and leadership provided by the Pacific Neuroscience Institute. We would also like to thank Evoke Neuroscience for their support in the collection and analysis of qEEG data. This work is supported by the Pacific Neuroscience Institute Foundation, including the generous support ofWill and Cary Singleton and the McLoughlin family.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000893246500033
- Scopus ID
- 2-s2.0-85143916943
- Other Identifier
- 991021860727404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences