Journal article
Diffuse near-infrared spectroscopy prediction of healing in diabetic foot ulcers: A human study and cost analysis
Wound repair and regeneration, v 20(6), pp 911-917
01 Nov 2012
PMID: 23110417
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Wound size reduction has been the standard benchmark for determination of efficacy for diabetic ulcer treatments but due to interclinician error and difficulty measuring irregular wound shapes, this method is unreliable with a positive predictive value of less than 60%. Diffuse near-infrared spectroscopy (DNIRS) uses 70-MHz modulated light in the diagnostic window (650-900 nm) noninvasively to quantify levels of oxy- and deoxy-hemoglobin in the wound bed, which when measured over time, can show a trend toward or away from healing based on the changes in oxy-hemoglobin concentration from week to week. In this study, DNIRS was used to monitor 24 human diabetic foot ulcers longitudinally over the course of 20 weekly or biweekly measurement sessions. In just 4 weeks, the DNIRS system has an 82% positive predictive value (sensitivity of 0.9 and specificity of 0.86; p < 0.002). These data indicate that it could be possible to predict healing in 4 weeks using DNIRS, which can provide objective guidance toward the continuation of costly treatments. Discontinuing ineffective treatments after 4 weeks could have potentially saved over $12,600 per patient, based on the treatment regimen of patients in this study.
Metrics
Details
- Title
- Diffuse near-infrared spectroscopy prediction of healing in diabetic foot ulcers: A human study and cost analysis
- Creators
- Michael S. Weingarten - Drexel UniversityJoshua A. Samuels - Drexel UniversityMichael Neidrauer - Drexel UniversityXiang Mao - Drexel UniversityDavid Diaz - Drexel UniversityJames McGuire - Temple UniversityJane McDaniel - Drexel UniversityLori Jenkins - Drexel UniversityLeonid Zubkov - Drexel UniversityElisabeth S. Papazoglou - Drexel University
- Publication Details
- Wound repair and regeneration, v 20(6), pp 911-917
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- 21702-5014 / US Army Medical Research Acquisition Activity, Chandler Street, Fort Detrick, MD W81XWH 04-1-0419 / US Army Medical Research Acquisition Activity
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000310680200016
- Scopus ID
- 2-s2.0-84868542957
- Other Identifier
- 991019168676304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Dermatology
- Medicine, Research & Experimental
- Surgery