Journal article
Diffuse photon density wave measurements and Monte Carlo simulations
Journal of biomedical optics, v 20(10), pp 105006-105006
Oct 2015
PMID: 26465614
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Diffuse photon density wave (DPDW) methodology is widely used in a number of biomedical applications. Here, we present results of Monte Carlo simulations that employ an effective numerical procedure based upon a description of radiative transfer in terms of the Bethe–Salpeter equation. A multifrequency noncontact DPDW system was used to measure aqueous solutions of intralipid at a wide range of source–detector separation distances, at which the diffusion approximation of the radiative transfer equation is generally considered to be invalid. We find that the signal–noise ratio is larger for the considered algorithm in comparison with the conventional Monte Carlo approach. Experimental data are compared to the Monte Carlo simulations using several values of scattering anisotropy and to the diffusion approximation. Both the Monte Carlo simulations and diffusion approximation were in very good agreement with the experimental data for a wide range of source–detector separations. In addition, measurements with different wavelengths were performed to estimate the size and scattering anisotropy of scatterers.
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Details
- Title
- Diffuse photon density wave measurements and Monte Carlo simulations
- Creators
- Vladimir L Kuzmin - St Petersburg UniversityMichael T Neidrauer - Drexel UniversityDavid Diaz - Drexel UniversityLeonid A Zubkov - Drexel University
- Publication Details
- Journal of biomedical optics, v 20(10), pp 105006-105006
- Publisher
- Society of Photo-Optical Instrumentation Engineers (SPIE)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000366017100013
- Scopus ID
- 2-s2.0-84944894796
- Other Identifier
- 991019168785304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemical Research Methods
- Optics
- Radiology, Nuclear Medicine & Medical Imaging