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Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer
Journal article   Open access   Peer reviewed

Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer

Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, …
Journal of experimental & clinical cancer research, v 36(1), pp 68-68
15 May 2017
DOI: https://doi.org/10.1186/s13046-017-0531-3
PMID: 28506239
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1186/s13046-017-0531-3View
Published, Version of Record (VoR) Open

Abstract

Animals Antineoplastic Agents - pharmacology Artemisinins - pharmacology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism cdc42 GTP-Binding Protein - metabolism Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Disease Models, Animal Female Gallbladder Neoplasms - genetics Gallbladder Neoplasms - metabolism Gallbladder Neoplasms - mortality Gallbladder Neoplasms - pathology Heterografts Humans Mice Neoplasm Metastasis Neoplasm Staging Tumor Protein, Translationally-Controlled 1
Patients with metastatic or relapsed gallbladder cancer generally have a poor prognosis. Therefore, targeting metastasis is one arm of therapeutic strategies to treat gallbladder cancer. Levels of translationally controlled tumor protein (TCTP) were measured in samples of gallbladder cancer by immunohistochemical staining. Wound healing, migration and invasion assays were used to investigate the motility of cells. Western blot assay was used to investigate the levels of TCTP and other proteins. Liver metastasis models and lung metastasis models were established to investigate the inhibitory effect of Dihydroartemisinin on gallbladder cancer metastasis. TCTP is aberrantly expressed in gallbladder cancer patients and associated with metastasis and a poor prognosis. Depleting TCTP significantly inhibited gallbladder cancer cell migration and invasion. We found that Dihydroartemisinin as a potent inhibitor of TCTP inhibited TCTP-dependent cell migration and invasion by reducing cell division control protein 42 homolog (Cdc42) activation. In addition, in mice with xenografted tumors, treatment with Dihydroartemisinin decreased gallbladder cancer cell metastases and improved survival. These findings provide new insights into the therapeutic activity of Dihydroartemisinin as a treatment for gallbladder cancer metastasis.

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54 citations in Web of Science
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Collaboration types
Domestic collaboration
Web of Science research areas
Oncology
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