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Direct Assessment of Wall Shear Stress by Signal Intensity Gradient from Time-of-Flight Magnetic Resonance Angiography
Journal article   Open access   Peer reviewed

Direct Assessment of Wall Shear Stress by Signal Intensity Gradient from Time-of-Flight Magnetic Resonance Angiography

Kap-Soo Han, Sang Hyuk Lee, Han Uk Ryu, Se-Hyoung Park, Gyung-Ho Chung, Young I Cho and Seul-Ki Jeong
BioMed research international, v 2017, pp 7087086-8
2017
DOI: https://doi.org/10.1155/2017/7087086
PMID: 28900625
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1155/2017/7087086View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

Cardiovascular Diseases - diagnosis Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - physiopathology Carotid Arteries Carotid Artery, Common - diagnostic imaging Carotid Artery, Common - physiopathology Carotid Stenosis - diagnosis Carotid Stenosis - diagnostic imaging Carotid Stenosis - physiopathology Contrast Media - therapeutic use Humans Hydrodynamics Magnetic Resonance Angiography - methods Magnetic Resonance Imaging - methods
The aim of the study was to calculate the arterial wall signal intensity gradient (SIG) from time-of-flight MR angiography (TOF-MRA) and represent arterial wall shear stress. We developed a new algorithm that uses signal intensity (SI) of a TOF-MRA to directly calculate the signal intensity gradient (SIG). The results from our phantom study showed that the TOF-MRA SIG could be used to distinguish the magnitude of blood flow rate as high (mean SIG ± SD, 2.2 ± 0.4 SI/mm for 12.5 ± 2.3 L/min) and low (0.9 ± 0.3 SI/mm for 8.5 ± 2.6 L/min) in vessels ( < 0.001). Additionally, we found that the TOF-MRA SIG values were highly correlated with various flow rates ( = 0.96, < 0.001). Remarkably, the correlation coefficient between the WSS obtained from the computational fluid dynamics (CFD) analysis and the TOF-MRA SIG was greater than 0.8 in each section at the carotid artery ( < 0.001 for all values). This new technique using TOF-MRA could enable the rapid calculation of the TOF-MRA SIG and thereby the WSS. Thus, the TOF-MRA SIG can provide clinicians with an accurate and efficient screening method for making rapid decisions on the risk of vascular disease for a patient in clinical practice.

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14 citations in Web of Science
13 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Biotechnology & Applied Microbiology
Medicine, Research & Experimental
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