Journal article
Direct Noninvasive Assessment of Brain Metabolism during Increased Intracranial Pressure: Potential Therapeutic Vistas
The journal of trauma, v 26(10), pp 863-868
Oct 1986
PMID: 3021965
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intracranial pressure was increased in cats by infusing ‘mock’ CSF intracranially, thus decreasing cerebral perfusion and oxygenation. The cats then randomly received either 50% 02 or 50% 02—5% CO2 by inhalation. As monitored by in vivo near-infrared spectroscopy (NIR), no improvement was noted after 50% O2 whereas 50% O2-5% C02 resulted in increased perfusion, an oxidation of cytochrome a,a3, an increase in oxyhemoglobin, and reduced quantities of de-oxyhemoglobin (p < 0.01) despite a further increase in intracranial pressure. The authors conclude thata) NIK is a useful means of noninvasively and directly assessing brain metabolism and has advantages over simple ICP monitoring; and b) continued investigations of C02 as a possible therapeutic modality after head injury appear warranted.
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Details
- Title
- Direct Noninvasive Assessment of Brain Metabolism during Increased Intracranial Pressure: Potential Therapeutic Vistas
- Creators
- CHARLES Cairns - University of North Carolina at Chapel HillDREW Fillipo - University of North Carolina at Chapel HillG WILLIAM Palladino - University of North Carolina at Chapel HillHERBERT Proctor - University of North Carolina at Chapel Hill
- Publication Details
- The journal of trauma, v 26(10), pp 863-868
- Publisher
- Williams & Wilkins
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:A1986E548000001
- Scopus ID
- 2-s2.0-0022979056
- Other Identifier
- 991021463436304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Critical Care Medicine
- Surgery