Journal article
Direct and controllable nitric oxide delivery into biological media and living cells by a pin-to-hole spark discharge (PHD) plasma
Journal of physics. D, Applied physics, v 44(7), p075201
23 Feb 2011
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nitric oxide has great potential for improving wound healing through both inflammatory and vascularization processes. Nitric oxide can be produced in high concentrations by atmospheric pressure thermal plasmas. We measured the physical characteristics and nitric oxide production of a pin-to-hole spark discharge (PHD) plasma, as well as plasma-produced nitric oxide delivery into liquid and endothelial cells. The plasma temperature was calculated as 9030 +/- 320K by the Boltzmann method, which was adequate to produce nitric oxide, although the average gas temperature was near room temperature. The plasma produced significant UV radiation and hydrogen peroxide, but these were prevented from reaching the cells by adding a straight or curved tube extension to the plasma device. Plasma-produced nitric oxide in gas reached 2000 ppm and rapidly diffused into liquid and cells. Cells remained viable following plasma treatment and showed a linear increase in cGMP concentration with plasma treatment, indicating an intracellular functional response to PHD plasma NO. These data suggest that this plasma may provide a novel method for delivering NO locally and directly for enhanced wound healing.
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Details
- Title
- Direct and controllable nitric oxide delivery into biological media and living cells by a pin-to-hole spark discharge (PHD) plasma
- Creators
- D. Dobrynin - Drexel UniversityK. Arjunan - Drexel UniversityA. Fridman - Drexel UniversityG. Friedman - Drexel UniversityA. Morss Clyne - Drexel University
- Publication Details
- Journal of physics. D, Applied physics, v 44(7), p075201
- Publisher
- Iop Publishing Ltd
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; C. and J. Nyheim Plasma Institute; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000286883800011
- Scopus ID
- 2-s2.0-79751470403
- Other Identifier
- 991019168317604721
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- Web of Science research areas
- Physics, Applied