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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Direct determination of haplotypes from single DNA molecules
Nature methods, v 6(3), pp 199-201
01 Mar 2009
PMID: 19198595
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Determining the long-range haplotypes in a diploid individual is a major technical challenge. Here we report a method of molecular haplotyping by directly imaging multiple polymorphic sites on individual human DNA molecules simultaneously. We demonstrate the utility of this technology by accurately determining the haplotypes consisting of up to 16 single-nucleotide polymorphisms in genomic regions up to 50 kilobases.
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Details
- Title
- Direct determination of haplotypes from single DNA molecules
- Creators
- Ming Xiao - Drexel University, School of Biomedical Engineering, Science, and Health SystemsEunice Wan - University of California, San FranciscoCatherine Chu - University of California, San FranciscoWen-Chi Hsueh - University of California, San FranciscoYang Cao - University of California, San FranciscoPui-Yan Kwok - University of California, San Francisco
- Publication Details
- Nature methods, v 6(3), pp 199-201
- Publisher
- Springer Nature
- Number of pages
- 3
- Grant note
- R01HG001720 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) R01-HG01720 / US National Human Genome Research Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000263723300012
- Scopus ID
- 2-s2.0-61449165662
- Other Identifier
- 991020637013904721
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- Web of Science research areas
- Biochemical Research Methods