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Direct intra-accumbal infusion of a beta-adrenergic receptor antagonist abolishes WIN 55,212-2-induced aversion
Journal article   Open access   Peer reviewed

Direct intra-accumbal infusion of a beta-adrenergic receptor antagonist abolishes WIN 55,212-2-induced aversion

Ana Franky Carvalho and Elisabeth J Van Bockstaele
Neuroscience letters, v 500(1), pp 82-85
01 Aug 2011
DOI: https://doi.org/10.1016/j.neulet.2011.06.008
PMID: 21693171
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc3232734View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Adrenergic beta-1 Receptor Antagonists - pharmacology Animals Avoidance Learning - drug effects Benzoxazines - pharmacology Betaxolol - administration & dosage Betaxolol - pharmacology Cannabinoids - pharmacology Conditioning, Psychological Lithium Chloride - pharmacology Male Microinjections Morpholines - pharmacology Naphthalenes - pharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 - agonists
The cannabinoid system is known to interact with a variety of neuromodulators in the central nervous system and impacts diverse behaviors. Previous studies have demonstrated that limbic norepinephrine is a critical determinant in the behavioral expression of cannabinoid-induced aversion. The present study was carried out to define the adrenergic receptor subtype involved in mediating cannabinoid-induced behavioral responses. An acute microinjection of the β1-adrenergic receptor blocker, betaxolol, directly into the nucleus accumbens (Acb), was able to prevent WIN 55,212-2-induced aversion, but not lithium-induced aversion, as measured in a place conditioning paradigm. These results suggest that noradrenergic transmission in the Acb is important for cannabinoid-induced aversion and that beta-adrenergic antagonists may be effective in counteracting negative side effects of cannabinoid-based agents.

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9 citations in Web of Science
11 citations in Scopus

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