Journal article
Discerning the Ancestry of European Americans in Genetic Association Studies
PLoS genetics, v 4(1), pp 0009-0017
01 Jan 2008
PMID: 18208327
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is important in order to prevent false-positive or false-negative associations due to population stratification and to identify genetic variants whose contribution to disease risk differs across European ancestries. Here, we investigate empirical patterns of population structure in European Americans, analyzing 4,198 samples from four genome-wide association studies to show that components roughly corresponding to northwest European, southeast European, and Ashkenazi Jewish ancestry are the main sources of European American population structure. Building on this insight, we constructed a panel of 300 validated markers that are highly informative for distinguishing these ancestries. We demonstrate that this panel of markers can be used to correct for stratification in association studies that do not generate dense genotype data.
Metrics
Details
- Title
- Discerning the Ancestry of European Americans in Genetic Association Studies
- Creators
- Alkes L Price - Harvard UniversityJohannah Butler - Broad InstituteNick PattersonCristian Capelli - University of OxfordVincenzo L Pascali - Università Cattolica del Sacro CuoreFrancesca Scarnicci - Università Cattolica del Sacro CuoreAndres Ruiz-Linares - University College LondonLeif Groop - Lund UniversityAngelica A Saetta - National and Kapodistrian University of AthensPenelope Korkolopoulou - National and Kapodistrian University of AthensUri Seligsohn - Sheba Medical CenterAlicja Waliszewska - Broad InstituteChristine Schirmer - Broad InstituteKristin Ardlie - Broad InstituteAlexis Ramos - Boston Children's HospitalJames Nemesh - Boston Children's HospitalLori Arbeitman - Boston Children's HospitalDavid B Goldstein - Duke UniversityDavid Reich - Broad InstituteJoel N Hirschhorn - Broad Institute
- Publication Details
- PLoS genetics, v 4(1), pp 0009-0017
- Publisher
- Public Library of Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000255378700006
- Scopus ID
- 2-s2.0-38949104183
- Other Identifier
- 991021958686504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity