Journal article
Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein
Bioorganic & medicinal chemistry letters, Vol.23(4), pp.1132-1135
15 Feb 2013
PMCID: PMC3557583
PMID: 23305922
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Due to the emergence of drug-resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The HIV-1 matrix (MA) protein is an essential viral component with established roles in the assembly of the virus. Using virtual and surface plasmon resonance (SPR)-based screening, we describe the identification of the first small molecule to bind to the HIV-1 MA protein and to possess broad range anti-HIV properties.
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Details
- Title
- Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein
- Creators
- Isaac Zentner - Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USALuz-Jeannette Sierra - Department of Microbiology & Immunology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USALina Maciunas - Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USAAndrei Vinnik - QuantumLead, Quantum Pharmaceuticals, Moscow, RussiaPeter Fedichev - QuantumLead, Quantum Pharmaceuticals, Moscow, RussiaMarie K Mankowski - Department of Infectious Disease Research, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USARoger G Ptak - Department of Infectious Disease Research, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USAJulio Martín-García - Department of Microbiology & Immunology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USASimon Cocklin - Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USA
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.23(4), pp.1132-1135
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Microbiology and Immunology
- Identifiers
- 991014878189704721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic