Journal article
Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues
Bioorganic & medicinal chemistry letters, v 17(21), pp 5928-5933
01 Nov 2007
PMID: 17869100
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A novel class of Growth Hormone Secretagogues (GHS), based on a tetrazole template, has been discovered. In vitro SAR and in vivo potency within this new class of GHS are described. The tetrazole
9q exhibits good oral bioavailability in rats and dogs as well as efficacy following an oral 10
mg/kg dose in dogs. Solution and solid phase protocols for the synthesis of tetrazole based GHS have been developed.
A novel class of Growth Hormone Secretagogues (GHS), based on a tetrazole template, has been discovered. In vitro SAR and in vivo potency within this new class of GHS are described. The tetrazole
9q exhibits good oral bioavailability in rats and dogs as well as efficacy following an oral 10
mg/kg dose in dogs. Solution and solid phase protocols for the synthesis of tetrazole based GHS have been developed.
Metrics
Details
- Title
- Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues
- Creators
- Andrés S. Hernández - Bristol-Myers Squibb (Germany)Peter T.W. Cheng - Bristol-Myers Squibb (United States)Christa M. Musial - Bristol-Myers Squibb (Germany)Stephen G. Swartz - Bristol-Myers Squibb (Germany)Rocco J. George - Bristol-Myers Squibb (United States)Gary Grover - Bristol-Myers Squibb (United States)Dorothy Slusarchyk - Bristol-Myers Squibb (United States)R. Krishna Seethala - Metabolic Disease Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USAMark Smith - Bristol-Myers Squibb (United States)Kenneth Dickinson - Metabolic Disease Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USALeah Giupponi - Bristol-Myers Squibb (United States)Daniel A. Longhi - Bristol-Myers Squibb (United States)Neil Flynn - Bristol-Myers Squibb (United States)Brian J. Murphy - Bristol-Myers Squibb (United States)David A. Gordon - Bristol-Myers Squibb (United States)Scott A. Biller - Bristol-Myers Squibb (Germany)Jeffrey A. Robl - Bristol-Myers Squibb (Germany)Joseph A. Tino - Bristol-Myers Squibb (Germany)
- Publication Details
- Bioorganic & medicinal chemistry letters, v 17(21), pp 5928-5933
- Publisher
- Elsevier
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000250287800037
- Scopus ID
- 2-s2.0-34548851728
- Other Identifier
- 991021902531404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic