Journal article
Disease damage and low bone mineral density: an analysis of women with systemic lupus erythematosus ever and never receiving corticosteroids
Rheumatology (Oxford, England), v 45(1), pp 53-60
Jan 2006
PMID: 16278288
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives. To evaluate the relationship between disease damage and bone mineral density (BMD) in women with systemic lupus erythematosus (SLE). Methods. A cross-sectional study was conducted among 307 women with SLE. Patients attended a single clinic visit that included an interview, physical examination, laboratory testing and BMD measurements (hip and/or lumbar spine). Women were stratified by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology cumulative disease damage index (SDI) ≥1 (Damage) vs SDI=0 (No Damage), and prior use of corticosteroids (CS), yielding four groups: (1) Damage/CS+ (n=138), (2) Damage/CS− (n=23), (3) no Damage/CS− (n=100), and (4) no Damage/CS− (n=46). Results. Mean age at SLE diagnosis was 32.7 ± 11.8 yr, 24.4% were African American, 65.0% were premenopausal, and mean SDI ± s.d. was 1.3 ± 1.8. In the unadjusted and adjusted models controlling for significant univariate risk factors for osteoporosis, the reference group (Group 1) had significantly lower mean BMD T-scores at the hip and lumbar spine than groups having no disease damage (Groups 3 and 4) independent of CS use status. Similar hip and lumbar spine mean BMD T-scores were observed in women with disease damage with and without CS exposure (Groups 1 and 2). Conclusions. Women with SLE having disease damage and no CS use had BMD T-scores at the hip and lumbar spine similar to those of women with disease damage and prior CS use. These findings suggest an association between disease damage and lower BMD T-scores in women with SLE.
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Details
- Title
- Disease damage and low bone mineral density: an analysis of women with systemic lupus erythematosus ever and never receiving corticosteroids
- Creators
- C. Lee - Northwestern UniversityO. Almagor - Northwestern UniversityD. D. Dunlop - Center for RheumatologyS. Manzi - University of PittsburghS. Spies - Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL andA. B. Chadha - Northwestern UniversityR. Ramsey-Goldman - Center for Rheumatology
- Publication Details
- Rheumatology (Oxford, England), v 45(1), pp 53-60
- Publisher
- Oxford University Press
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000234220600011
- Scopus ID
- 2-s2.0-29844439395
- Other Identifier
- 991021934013904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology