Logo image
Disease modifying drugs targeting β-amyloid
Journal article   Open access   Peer reviewed

Disease modifying drugs targeting β-amyloid

S N Ozudogru and C F Lippa
American journal of Alzheimer's disease and other dementias, v 27(5)
Aug 2012
PMID: 22815077
url
https://doi.org/10.1177/1533317512452034View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Amyloid beta-Peptides - drug effects Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases - antagonists & inhibitors Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antibodies, Monoclonal, Humanized - therapeutic use Enzyme Inhibitors - therapeutic use Glucagon-Like Peptides - therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Methylene Blue - therapeutic use Nootropic Agents - therapeutic use
At this time there are no effective methods to alter the disease course in Alzheimer's disease. All FDA approved interventions are for symptomatic relief only. However, it is an exciting time as many agents in development have theorhetical potential to impact the disease course. This review discusses some of the agents that have been in clinical trials, particularly those that affect amyloid processing. Some agents have failed while others still provide hope. Since amyloid is the peptide most closely linked to disease pathogenesis, it is possible that some of the anti-amyloid agents will impact the disease progression in a meaningful way.

Metrics

3 Record Views
25 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Web of Science research areas
Clinical Neurology
Geriatrics & Gerontology
Logo image