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Disparities in Stroke Incidence Contributing to Disparities in Stroke Mortality
Journal article   Open access   Peer reviewed

Disparities in Stroke Incidence Contributing to Disparities in Stroke Mortality

Virginia J. Howard, Dawn O. Kleindorfer, Suzanne E. Judd, Leslie A. McClure, Monika M. Safford, J. David Rhodes, Mary Cushman, Claudia S. Moy, Elsayed Z. Soliman, Brett M. Kissela, …
Annals of neurology, v 69(4), pp 619-627
01 Apr 2011
DOI: https://doi.org/10.1002/ana.22385
PMID: 21416498
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc3595534View
Accepted (AM) Open Open Access (License Unspecified)

Abstract

Clinical Neurology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Science & Technology
Objective: While black-white and regional disparities in U. S. stroke mortality rates are well documented, the contribution of disparities in stroke incidence is unknown. We provide national estimates of stroke incidence by race and region, contrasting these to publicly available stroke mortality data. Methods: This analysis included 27,744 men and women without prevalent stroke (40.4% black), aged >= 45 years from the REasons for Geographic And Racial Differences in Stroke (REGARDS) national cohort study, enrolled 2003-2007. Incident stroke was defined as first occurrence of stroke over 4.4 years of follow-up. Age-sex-adjusted stroke mortality rates were calculated using data from the Centers for Disease Control and Prevention (CDC) Wide-Ranging Online Data for Epidemiological Research (WONDER) System. Results: There were 460 incident strokes over 113,469 person-years of follow-up. Relative to the rest of the United States, incidence rate ratios (IRRs) of stroke in the southeastern stroke belt and stroke buckle were 1.06 (95% confidence interval [CI], 0.87-1.29) and 1.19 (95% CI, 0.96-1.47), respectively. The age-sex-adjusted black/white IRR(black) was 1.51 (95% CI, 1.26-1.81), but for ages 45-54 years the IRR(black) was 4.02 (95% CI, 1.23-13.11) while for ages 85+ it was 0.86 (95% CI, 0.33-2.20). Generally, the IRRs(black) were less than the mortality rate ratios (MRRs) across age groups; however, only in ages 55-64 years and 65-74 years did the 95% CIs of IRRs(black) not include the MRR(black). The MRRs for regions were within 95% CIs for IRRs. Interpretation: National patterns of black-white and regional differences in stroke incidence are similar to those for stroke mortality; however, the magnitude of differences in incidence appear smaller. ANN NEUROL 2011; 69: 619-627

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Neurosciences
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