Journal article
Disproportionate Fetal Growth and the Risk for Congenital Cerebral Palsy in Singleton Births
PloS one, v 10(5), pp e0126743-e0126743
14 May 2015
PMID: 25974407
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
To investigate the association between proportionality of fetal and placental growth measured at birth and the risk for congenital cerebral palsy (CP).
Study Design
We identified all live-born singletons born in Denmark between 1995 and 2003 and followed them from 1 year of age until December 31st, 2008. Information on four indices of fetal growth: ponderal index, head circumference/abdominal circumference ratio, cephalization index and birth weight/placenta weight ratio was collected. Cox proportional hazards regression models were used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI). All measurements were evaluated as gestational age and sex specific z-scores and in z-score percentile groups, adjusted for potential confounders, and stratified on gestational age groups (< 32, 32-36, 37-38, 39, 40, >= 41 weeks).
Results
We identified 503,784 singleton births, of which 983 were confirmed cases of CP. Head/abdominal circumference ratio (aHR: 1.12; 95% CI: 1.07-1.16) and cephalization index (aHR: 1.14; 95% CI: 1.11-1.16) were associated with the risk of CP irrespective of gestational age. Birth weight-placental weight ratio was also associated with CP in the entire cohort (aHR: 0.90; 95% CI: 0.83-0.97). Ponderal index had a u-shaped association with CP, where both children with low and high ponderal index were at higher risk of CP.
Conclusions
CP is associated with disproportions between birth weight, birth length, placental weight and head circumference suggesting pre and perinatal conditions contribute to fetal growth restriction in children with CP.
Metrics
Details
- Title
- Disproportionate Fetal Growth and the Risk for Congenital Cerebral Palsy in Singleton Births
- Creators
- Elani Streja - University of California, Los AngelesJessica E. Miller - University of California, Los AngelesChunsen Wu - Aarhus University HospitalBodil H. Bech - Aarhus UniversityLars Henning Pedersen - Aarhus University HospitalDiana E. Schendel - Aarhus UniversityPeter Uldall - University of CopenhagenJorn Olsen - Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA
- Publication Details
- PloS one, v 10(5), pp e0126743-e0126743
- Publisher
- Public Library Science
- Number of pages
- 14
- Grant note
- Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark R155-2014-1724 / Lundbeck Foundation; Lundbeckfonden
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000354545600080
- Scopus ID
- 2-s2.0-84929340275
- Other Identifier
- 991021230003504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics