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Journal article
Disrupted functional connectivity of cerebellar default network areas in attention-deficit/hyperactivity disorder
Human brain mapping, v 36(9), pp 3373-3386
Sep 2015
PMID: 26109476
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is increasingly understood as a disorder of spontaneous brain-network interactions. The default mode network (DMN), implicated in ADHD-linked behaviors including mind-wandering and attentional fluctuations, has been shown to exhibit abnormal spontaneous functional connectivity (FC) within-network and with other networks (salience, dorsal attention and frontoparietal) in ADHD. Although the cerebellum has been implicated in the pathophysiology of ADHD, it remains unknown whether cerebellar areas of the DMN (CerDMN) exhibit altered FC with cortical networks in ADHD. Here, 23 adults with ADHD and 23 age-, IQ-, and sex-matched controls underwent resting state fMRI. The mean time series of CerDMN areas was extracted, and FC with the whole brain was calculated. Whole-brain between-group differences in FC were assessed. Additionally, relationships between inattention and individual differences in FC were assessed for between-group interactions. In ADHD, CerDMN areas showed positive FC (in contrast to average FC in the negative direction in controls) with widespread regions of salience, dorsal attention and sensorimotor networks. ADHD individuals also exhibited higher FC (more positive correlation) of CerDMN areas with frontoparietal and visual network regions. Within the control group, but not in ADHD, participants with higher inattention had higher FC between CerDMN and regions in the visual and dorsal attention networks. This work provides novel evidence of impaired CerDMN coupling with cortical networks in ADHD and highlights a role of cerebro-cerebellar interactions in cognitive function. These data provide support for the potential targeting of CerDMN areas for therapeutic interventions in ADHD. Hum Brain Mapp 36:3373-3386, 2015. (c) 2015 Wiley Periodicals, Inc.
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Details
- Title
- Disrupted functional connectivity of cerebellar default network areas in attention-deficit/hyperactivity disorder
- Creators
- Aaron Kucyi - Harvard UniversityMichael J. Hove - Harvard UniversityJoseph Biederman - Massachusetts General HospitalKoene R. A. Van Dijk - Athinoula A. Martinos Center for Biomedical ImagingEve M. Valera - Harvard University
- Publication Details
- Human brain mapping, v 36(9), pp 3373-3386
- Publisher
- Wiley
- Number of pages
- 14
- Grant note
- Pediatric Psychopharmacology Council Fund T32MH016259 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01 HD067744-01A1; T32 MH16259; NCRR P41RR14075; P41 EB015896 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01HD067744 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) P41EB015896 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) P41RR014075 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000360209000006
- Scopus ID
- 2-s2.0-84939424519
- Other Identifier
- 991021448159204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging