Journal article
Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation
Cell reports (Cambridge), v 18(11), pp 2584-2591
14 Mar 2017
PMID: 28297663
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dopamine neurons in the ventral tegmental area (VTA) were previously found to express vesicular glutamate transporter 2 (VGLUT2) and to co-transmit glutamate in the ventral striatum (VStr). This capacity may play an important role in reinforcement learning. Although it is known that activation of the VTA-VStr dopamine system readily reinforces behavior, little is known about the role of glutamate co-transmission in such reinforcement. By combining electrode recording and optogenetics, we found that stimulation of VTA dopamine neurons in vivo evoked fast excitatory responses in many VStr neurons of adult mice. Whereas conditional knockout of the gene encoding VGLUT2 in dopamine neurons largely eliminated fast excitatory responses, it had little effect on the acquisition of conditioned responses reinforced by dopamine neuron activation. Therefore, glutamate co-transmission appears dispensable for acquisition of conditioned responding reinforced by DA neuron activation.
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•Glutamate co-release from DA neurons drives fast excitatory responses in VStr in vivo•Loss of VGLUT2 in DA neurons abolishes glutamate co-transmission•Such loss does not disrupt DA neurons from reinforcing behavior
Wang et al. find that targeted deletion of the gene encoding VGLUT2 in dopamine neurons largely eliminates fast excitatory responses caused by glutamate co-transmission in the ventral striatum in vivo. However, it has little effect on the acquisition of conditioned responses reinforced by the activation of VTA dopamine neurons.
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Details
- Title
- Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation
- Creators
- Dong V. Wang - National Institute on Drug AbuseThomas Viereckel - Uppsala UniversityVivien Zell - University of California San DiegoÅsa Konradsson-Geuken - Uppsala UniversityCarl J. Broker - National Institute on Drug AbuseAleksandr Talishinsky - National Institute on Drug AbuseJi Hoon Yoo - University of California San DiegoMelissa H. Galinato - University of California San DiegoEmma Arvidsson - Uppsala UniversityAndrew J. Kesner - National Institute on Drug AbuseThomas S. Hnasko - University of California San DiegoÅsa Wallén-Mackenzie - Uppsala UniversitySatoshi Ikemoto - National Institute on Drug Abuse
- Publication Details
- Cell reports (Cambridge), v 18(11), pp 2584-2591
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000397330000005
- Scopus ID
- 2-s2.0-85015192127
- Other Identifier
- 991020099047804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology