Journal article
Disruption of neuronal CXCR4 function by opioids: Preliminary evidence of Ferritin Heavy Chain as a potential etiological agent in neuroAIDS
Journal of neuroimmunology, v 224(1), pp 66-71
2010
PMID: 20627326
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The chemokine CXCL12 and its receptor, CXCR4, regulate neuronal migration, differentiation, and survival. Alterations of CXCL12/CXCR4 signaling are implicated in different neuropathologies, including the neurological complications of HIV infection. Opiates are important co-factors for progression to neuroAIDS and can disrupt the CXCL12/CXCR4 axis
in vitro and
in vivo. This paper will review recently identified mechanisms of opiate-induced CXCR4 impairment in neurons and introduce results from pilot studies in human brain tissue, which highlight the role of the protein ferritin heavy chain in HIV neuropathology in patients with history of drug abuse.
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Details
- Title
- Disruption of neuronal CXCR4 function by opioids: Preliminary evidence of Ferritin Heavy Chain as a potential etiological agent in neuroAIDS
- Creators
- Jonathan Pitcher - Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, United StatesSaori Shimizu - Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, United StatesSilvia Burbassi - Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, United StatesOlimpia Meucci - Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, United States
- Publication Details
- Journal of neuroimmunology, v 224(1), pp 66-71
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000280896500011
- Scopus ID
- 2-s2.0-77955086732
- Other Identifier
- 991014877941804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Neurosciences