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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Disruption of the Postsynaptic Density in Alzheimer's Disease and Other Neurodegenerative Dementias
American journal of Alzheimer's disease and other dementias, v 25(7), pp 547-555
01 Nov 2010
PMID: 20858652
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The most common causes of neurodegenerative dementia include Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). We believe that, in all 3, aggregates of pathogenic proteins are pathological substrates which are associated with a loss of synaptic function/plasticity. The synaptic plasticity relies on the normal integration of glutamate receptors at the postsynaptic density (PSD). The PSD organizes synaptic proteins to mediate the functional and structural plasticity of the excitatory synapse and to maintain synaptic homeostasis. Here, we will discuss the relevant disruption of the protein network at the PSD in these dementias and the accumulation of the pathological changes at the PSD years before clinical symptoms. We suggest that the functional and structural plasticity changes of the PSD may contribute to the loss of molecular homeostasis within the synapse (and contribute to early symptoms) in these dementias.
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Details
- Title
- Disruption of the Postsynaptic Density in Alzheimer's Disease and Other Neurodegenerative Dementias
- Creators
- Yuesong Gong - Drexel UniversityCarol F. Lippa - Drexel University
- Publication Details
- American journal of Alzheimer's disease and other dementias, v 25(7), pp 547-555
- Publisher
- Sage
- Number of pages
- 9
- Grant note
- R21AG031388 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Potamkin Foundation
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000282645000002
- Scopus ID
- 2-s2.0-77957954675
- Other Identifier
- 991019312378604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Geriatrics & Gerontology