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Journal article
Dissociating Movement from Movement Timing in the Rat Primary Motor Cortex
The Journal of neuroscience, v 34(47), pp 15576-15586
19 Nov 2014
PMID: 25411486
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neural encoding of the passage of time to produce temporally precise movements remains an open question. Neurons in several brain regions across different experimental contexts encode estimates of temporal intervals by scaling their activity in proportion to the interval duration. In motor cortex the degree to which this scaled activity relies upon afferent feedback and is guided by motor output remains unclear. Using a neural reward paradigm to dissociate neural activity from motor output before and after complete spinal transection, we show that temporally scaled activity occurs in the rat hindlimb motor cortex in the absence of motor output and after transection. Context-dependent changes in the encoding are plastic, reversible, and re-established following injury. Therefore, in the absence of motor output and despite a loss of afferent feedback, thought necessary for timed movements, the rat motor cortex displays scaled activity during a broad range of temporally demanding tasks similar to that identified in other brain regions.
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Details
- Title
- Dissociating Movement from Movement Timing in the Rat Primary Motor Cortex
- Creators
- Eric B. Knudsen - Drexel University School of Biomedical Engineering and Health Sciences and.Marissa E. Powers - Drexel UniversityKaren A. Moxon - Drexel University
- Publication Details
- The Journal of neuroscience, v 34(47), pp 15576-15586
- Publisher
- Soc Neuroscience
- Number of pages
- 11
- Grant note
- 89500 / Shriners Hospital for Children NS057419 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P113 / Internationale Stifung fur Forschung in Paraplegie
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000345907500007
- Scopus ID
- 2-s2.0-84911403182
- Other Identifier
- 991019168853804721
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- Web of Science research areas
- Neurosciences