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Journal article
Dissociating the incubation of appetitive and consummatory behavior in a model of oral cocaine self-administration
Pharmacology, biochemistry and behavior, v 254, 174055
Sep 2025
PMID: 40582418
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Cocaine use disorder remains a persistent public health dilemma that currently lacks effective treatment strategies. One key impediment to successful treatment outcomes is increased drug craving that occurs over the course of abstinence and subsequent relapse to drug use. This phenomenon, known as the incubation of drug craving, has been modeled extensively in rodent models of intravenous drug self-administration. The design of most intravenous self-administration studies examining the incubation effect precludes disentangling appetitive and consummatory behaviors as drug seeking (appetitive) and taking (consummatory) is simultaneous. Here, we employed a model of oral cocaine self-administration to interrogate the incubation of drug vs nondrug craving, where the route of administration is identical between reinforcers and appetitive and consummatory behaviors are dissociable. Oral self-administration of cocaine produced detectable levels of cocaine and its metabolite, benzoylecgonine, within the blood and brain, and tissue levels of both substrates correlated with cocaine consumption. When tested for seeking- (lever pressing) and taking-related (magazine head entries) behavior after 1 or 21 days of forced abstinence, we observed incubation of lever pressing among cocaine-administering mice and incubation of magazine entries among saccharin-administering mice. These behavioral changes were accompanied by reduced expression of the glial glutamate transporter GLT-1 within the nucleus accumbens (NAc) of cocaine self-administering mice, regardless of abstinence. Altogether, these results underscore the utility of this model of cocaine self-administration, highlight the conserved nature of incubated cocaine seeking across routes of administration, and demonstrate the dissociable neurobehavioral sequelae of the incubation of reward seeking across reinforcer types.
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Details
- Title
- Dissociating the incubation of appetitive and consummatory behavior in a model of oral cocaine self-administration
- Creators
- Mark Douglas Namba - Drexel University, Pharmacology and PhysiologySamuel L. Goldberg - Drexel UniversityChristine Marie Side - Drexel University, Pharmacology and PhysiologyAbhiram Yadlapalli - Drexel UniversityChristina M Curran-Alfaro - Drexel UniversityDevin KressMelissa F. FogartyAmanda L.A. MohrJacqueline M Barker (Corresponding Author) - Drexel University, Pharmacology and Physiology
- Publication Details
- Pharmacology, biochemistry and behavior, v 254, 174055
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- NIH: DP2DA051907, DP2DA051907-01S1, F32DA060768
These studies were supported by NIH grants DP2DA051907 and DP2DA051907-01S1 (Jacqueline M Barker) , F32DA060768 (Mark D Namba) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001526764300001
- Scopus ID
- 2-s2.0-105009294335
- Other Identifier
- 991022058835204721
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- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy