Journal article
Distinct Patterns of Temporal and Directional Connectivity among Intrinsic Networks in the Human Brain
The Journal of neuroscience, v 37(40), pp 9667-9674
04 Oct 2017
PMID: 28893929
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine the spatiotemporal relationships among intrinsic networks of the human brain, we recruited seven neurosurgical patients (four males and three females) who were implanted with intracranial depth electrodes. We first identified canonical resting-state networks at the individual subject level using an iterative matching procedure on each subject's resting-state fMRI data. We then introduced single electrical pulses to fMRI pre-identified nodes of the default network (DN), frontoparietal network (FPN), and salience network (SN) while recording evoked responses in other recording sites within the same networks. We found bidirectional signal flow across the three networks, albeit with distinct patterns of evoked responses within different time windows. We used a data-driven clustering approach to show that stimulation of the FPN and SN evoked a rapid (<70 ms) response that was predominantly higher within the SN sites, whereas stimulation of the DN led to sustained responses in later time windows (85-200 ms). Stimulations in the medial temporal lobe components of the DN evoked relatively late effects (>130 ms) in other nodes of the DN, as well as FPN and SN. Our results provide temporal information about the patterns of signal flow between intrinsic networks that provide insights into the spatiotemporal dynamics that are likely to constrain the architecture of the brain networks supporting human cognition and behavior.
Despite great progress in the functional neuroimaging of the human brain, we still do not know the precise set of rules that define the patterns of temporal organization between large-scale networks of the brain. In this study, we stimulated and then recorded electrical evoked potentials within and between three large-scale networks of the brain, the default network (DN), frontoparietal network (FPN), and salience network (SN), in seven subjects undergoing invasive neurosurgery. Using a data-driven clustering approach, we observed distinct temporal and directional patterns between the three networks, with FPN and SN activity predominant in early windows and DN stimulation affecting the network in later windows. These results provide important temporal information about the interactions between brain networks supporting human cognition and behavior.
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Details
- Title
- Distinct Patterns of Temporal and Directional Connectivity among Intrinsic Networks in the Human Brain
- Creators
- James M Shine - Stanford UniversityAaron Kucyi - Stanford UniversityBrett L Foster - Stanford UniversityStephan Bickel - Stanford UniversityDanhong Wang - Athinoula A. Martinos Center for Biomedical ImagingHesheng Liu - Athinoula A. Martinos Center for Biomedical ImagingRussell A Poldrack - Stanford UniversityLiang-Tien Hsieh - University of California, DavisJen Chun Hsiang - Stanford UniversityJosef Parvizi - Stanford University
- Publication Details
- The Journal of neuroscience, v 37(40), pp 9667-9674
- Publisher
- Society for Neuroscience
- Grant note
- R00 MH103479 / NIMH NIH HHS K01 MH111802 / NIMH NIH HHS R01 NS091604 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000412182900008
- Scopus ID
- 2-s2.0-85030661282
- Other Identifier
- 991021448051104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences