Journal article
Distinct patterns of gene expression in human cardiac fibroblasts exposed to rapamycin treatment or methionine restriction
Annals of the New York Academy of Sciences, v 1418(1), pp 95-105
01 Apr 2018
PMID: 29377178
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Both methionine restriction and rapamycin treatment are robust longevity-enhancing regimens for which the mechanisms remain unclear. Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin regimens delay or prevent activation of the senescence program in human cells. Using a transcriptome-wide analysis, we examined the impact of methionine restriction and rapamycin treatment on senescence-associated gene expression in human cardiac fibroblasts. Our findings have been integrated into gene expression data sets from human lung and skin fibroblasts during senescence. The data demonstrate both common and tissue-specific aspects to the senescent phenotype in these cell types. For example, cardiac fibroblasts express brain naturetic peptide, a clinically relevant marker for cardiac failure, whereas senescent cells from all three tissues express at least one of the insulin-like growth factor (IGF)-binding proteins. The IGF-binding proteins are tissue-specific mediators of IGF-1, a growth factor required for proliferation of all tissues. These data suggest that senescent cells serve tissue-specific roles. Moreover, the prolongevity regimens produce distinct patterns of gene expression.
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Details
- Title
- Distinct patterns of gene expression in human cardiac fibroblasts exposed to rapamycin treatment or methionine restriction
- Creators
- Ashley Azar - Drexel UniversityIbiyonu Lawrence - Drexel UniversitySebastian Jofre - Drexel UniversityJoshua Mell - Drexel UniversityChristian Sell - Drexel University
- Publication Details
- Annals of the New York Academy of Sciences, v 1418(1), pp 95-105
- Publisher
- Wiley
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Microbiology and Immunology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000431617400008
- Scopus ID
- 2-s2.0-85051816588
- Other Identifier
- 991019168055004721
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- Web of Science research areas
- Cell Biology