Journal article
Distinct temporal activity patterns in the rat M1 and red nucleus during skilled versus unskilled limb movement
Behavioural brain research, v 150(1), pp 93-107
2004
PMID: 15033283
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The mammalian motor system contains multiple interconnected supraspinal networks, but little is known about their relative roles in producing different movements and behaviors, particularly given their apparently fused activity in primates. We tested whether the task context, as well as using a phylogenetically older mammal, rats, could distinguish the separate contributions of these networks. We obtained simultaneous multi-single neuron recordings from the forelimb motor cortex and magnocellular red nucleus as rats performed two contextually different, but kinematically similar, forelimb reach-like tasks: highly learned, skilled reaching for food through a narrow slot [Behav. Brain Res. 41 (1990) 49], a task requiring extensive training, versus the swing phases of treadmill locomotion. In both the M1 and the mRN, large subpopulations of neurons peaked in their spike firing rates near the onset and the end of the swing phase during treadmill locomotion. In contrast, neural subgroups in the two areas displayed different temporal sequences of activity during the skilled reaching task. In the mRN, the majority of task-modulated neurons peaked in their firing rate in the middle of the reach when the rat was preparing to project the arm through the slot, whereas large subgroups of M1 neurons displayed elevated firing rates during the initial and terminal phases of the reach. These results suggest that motor-behavioral context can alter the degree of overlapping activity in different supraspinal sensorimotor networks. Moreover, results for the skilled reaching task in rats may have highlighted a distinct processing role of the rubral complex: adapting natural muscle synergies across joints and limbs to novel task demands, in concert with cortically based learning.
Metrics
Details
- Title
- Distinct temporal activity patterns in the rat M1 and red nucleus during skilled versus unskilled limb movement
- Creators
- L Hermer-Vazquez - SUNY Downstate Medical CenterR Hermer-Vazquez - SUNY Downstate Medical CenterK.A Moxon - Drexel UniversityK.-H Kuo - University of British ColumbiaV Viau - University of British ColumbiaY Zhan - SUNY Downstate Medical CenterJ.K Chapin - SUNY Downstate Medical Center
- Publication Details
- Behavioural brain research, v 150(1), pp 93-107
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000220607400011
- Scopus ID
- 2-s2.0-1642351905
- Other Identifier
- 991019168165304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences